biostudies-literatureUnknown9(11)Jun SY<h4>Background</h4>The assessment of tumor-infiltrating lymphocytes (TILs) has led to the development of various immunotherapies beyond their predictive potential in gastrointestinal malignancies. However, the clinicopathologic and prognostic values of TILs have yet to be well elucidated in distal extrahepatic bile duct carcinoma (DBDC).<h4>Patients and methods</h4>We evaluated stromal TILs (sTILs) and intraepithelial TILs (iTILs) in 405 surgically resected DBDCs to analyze their correlations with overall survival (OS) and recurrence-free survival (RFS) and with clinicopathologic parameters according to the eighth edition of the American Joint Committee on Cancer scheme.<h4>Results</h4>High levels of sTIL density (sTIL^High; >5%) and iTIL count (iTIL^High; >3) were founESMO open103969https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575191biostudies-literaturePrognostic value of tumor-infiltrating lymphocytes in distal extrahepatic bile duct carcinoma.PMC11575191Hong SMKim KPKim JYJun SYAn SfalsePrognostic value of tumor-infiltrating lymphocytes in distal extrahepatic bile duct carcinoma.<h4>Background</h4>The assessment of tumor-infiltrating lymphocytes (TILs) has led to the development of various immunotherapies beyond their predictive potential in gastrointestinal malignancies. However, the clinicopathologic and prognostic values of TILs have yet to be well elucidated in distal extrahepatic bile duct carcinoma (DBDC).<h4>Patients and methods</h4>We evaluated stromal TILs (sTILs) and intraepithelial TILs (iTILs) in 405 surgically resected DBDCs to analyze their correlations with overall survival (OS) and recurrence-free survival (RFS) and with clinicopathologic parameters according to the eighth edition of the American Joint Committee on Cancer scheme.<h4>Results</h4>High levels of sTIL density (sTIL^High; >5%) and iTIL count (iTIL^High; >3) were foun2024-01-01T00:00:00Z2024 Nov2025-04-04T20:39:11.592Z2025-04-04T20:39:11.592ZS-EPMC115751913951002110.1016/j.esmoop.2024.103969