biostudies-literatureHou LResearch and Development Program of Affiliated Hospital of North Sichuan Medical CollegeSchool Cooperation Research Fund of Nanchong CityScientific Research Projects of North Sichuan Medical College483https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575211biostudies-literatureUnknown24(1)<h4>Background</h4>Premature infants are more prone to brain injuries owing to incomplete nervous system development and poor adaptation outside the mother's body. Without timely intervention, premature infants with brain injuries often develop intellectual disabilities, causing significant burdens on families and the society. Multiple studies have shown that gut dysbiosis can affect the nervous system, and vice versa. This study aimed to explore the changes in gut microbiota of typical premature infants and those with brain injuries on the third and seventh days after birth using 16 S rRNA technology.<h4>Methods</h4>Fecal samples from typical premature infants (non-brain injury group, n = 17) and those with brain injuries (brain injury group, n = 21) were collected on days 1, 3, and 7 aftBMC microbiologyBrain injury in premature infants may be related to abnormal colonization of early gut microbiome.PMC1157521120SXZRKX003No. 2021ZK004 and No. 2021LC010CBY22-ZDA04Hou LDai LJiang LZhao JYin LDeng HfalseBrain injury in premature infants may be related to abnormal colonization of early gut microbiome.<h4>Background</h4>Premature infants are more prone to brain injuries owing to incomplete nervous system development and poor adaptation outside the mother's body. Without timely intervention, premature infants with brain injuries often develop intellectual disabilities, causing significant burdens on families and the society. Multiple studies have shown that gut dysbiosis can affect the nervous system, and vice versa. This study aimed to explore the changes in gut microbiota of typical premature infants and those with brain injuries on the third and seventh days after birth using 16 S rRNA technology.<h4>Methods</h4>Fecal samples from typical premature infants (non-brain injury group, n = 17) and those with brain injuries (brain injury group, n = 21) were collected on days 1, 3, and 7 aft2024-01-01T00:00:00Z2024 Nov2026-07-12T03:20:18.986Z2025-04-04T20:38:58.964ZS-EPMC115752113955826710.1186/s12866-024-03643-4