biostudies-literatureGe JNational “111” ProjectIndependent Exploration and Innovation Program of Central South UniversityHunan Provincial Key Research and Development ProgramBeijing Xisike Clinical Oncology Research Foundationthe scientific research program of FuRong laboratoryNatural Science Foundation of Hunan Province, ChinaThe National Natural Science Foundation of Chinae010091https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575282biostudies-literatureUnknown12(11)<h4>Background</h4>Nasopharyngeal carcinoma (NPC) is a distinct subtype of head and neck cancer which is prevalent in south of China and southeastern of Asia. Consistent activation of interferon (IFN) signaling, and impairment of T cell mediated antitumor immunity is frequent in NPC. Forkhead box A1 (FOXA1) is one of the earliest discovered pioneer factors, which can open up compact chromatin structures to facilitate the binding of other proteins to chromatin.<h4>Methods</h4>By using RNA sequencing, it was discovered that FOXA1 suppresses the activation of the interferon signaling pathway and the expression of the related interferon-responsive genes in NPC cells. The effect of FOXA1 on programmed death-ligand 1 (PD-L1) expression in C666-1 and HK1 cells under conditions with or without IFNJournal for immunotherapy of cancerFOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma.PMC11575282820725962022SK202682173339No.2023SK2094822726311053320221155YHR2020ZD-00522024JJ3036No. Project #111-2-12U23A20456Li GXiang BLiu YChen PYi MZeng ZGe JXiong WfalseFOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma.<h4>Background</h4>Nasopharyngeal carcinoma (NPC) is a distinct subtype of head and neck cancer which is prevalent in south of China and southeastern of Asia. Consistent activation of interferon (IFN) signaling, and impairment of T cell mediated antitumor immunity is frequent in NPC. Forkhead box A1 (FOXA1) is one of the earliest discovered pioneer factors, which can open up compact chromatin structures to facilitate the binding of other proteins to chromatin.<h4>Methods</h4>By using RNA sequencing, it was discovered that FOXA1 suppresses the activation of the interferon signaling pathway and the expression of the related interferon-responsive genes in NPC cells. The effect of FOXA1 on programmed death-ligand 1 (PD-L1) expression in C666-1 and HK1 cells under conditions with or without IFN2024-01-01T00:00:00Z2024 Nov2025-04-04T20:38:59.069Z2025-04-04T20:38:59.069ZS-EPMC115752823954265610.1136/jitc-2024-010091