biostudies-literatureYang BGuangxi University of Chinese Medicine-Shenzhen Kangtai Biological Products Co.Ltd. Guangxi Hepatitis B Prevention and Control ProjectGuangxi University of Chinese Medicine Guipai Xinglin Outstanding Talent Project| Natural Science Foundation of Guangxi Zhuang Autonomous Region (Guangxi Natural Science Foundation)广西壮族自治区科学技术厅 | Natural Science Foundation of Guangxi Zhuang Autonomous RegionHigh Level Talent Cultivation and Innovation Project of Guangxi University of Chinese Medicinee0081224https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575419biostudies-literatureUnknown9(11)Individuals with latent tuberculosis infection (LTBI) account for almost 30% of the population worldwide and have the potential to develop active tuberculosis (ATB). Despite this, the current understanding of the pathogenesis of LTBI is limited. The gut microbiome can be altered in tuberculosis patients, and an understanding of the changes associated with the progression from good health to LTBI to ATB can provide novel perspectives for understanding the pathogenesis of LTBI by identifying microbial and molecular biomarkers associated therewith. In this study, fecal samples from healthy controls (HC), individuals with LTBI and ATB patients were collected for gut microbiome and metabolomics analyses. Compared to HC and LTBI subjects, participants with ATB showed a significant decrease in gumSystemsAlterations in purine and pyrimidine metabolism associated with latent tuberculosis infection: insights from gut microbiome and metabolomics analyses.PMC11575419QT0220192022A0092017GXNSFAA01983302022C010Li HGuo XXu RShao KQin XYang BLuo DLiang DShi CGan LChen SZhong JLiu GMo YfalseAlterations in purine and pyrimidine metabolism associated with latent tuberculosis infection: insights from gut microbiome and metabolomics analyses.Individuals with latent tuberculosis infection (LTBI) account for almost 30% of the population worldwide and have the potential to develop active tuberculosis (ATB). Despite this, the current understanding of the pathogenesis of LTBI is limited. The gut microbiome can be altered in tuberculosis patients, and an understanding of the changes associated with the progression from good health to LTBI to ATB can provide novel perspectives for understanding the pathogenesis of LTBI by identifying microbial and molecular biomarkers associated therewith. In this study, fecal samples from healthy controls (HC), individuals with LTBI and ATB patients were collected for gut microbiome and metabolomics analyses. Compared to HC and LTBI subjects, participants with ATB showed a significant decrease in gu2024-01-01T00:00:00Z2024 Nov2025-04-04T20:38:41.408Z2025-04-04T20:38:41.408ZS-EPMC115754193943610310.1128/msystems.00812-24