{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(1)"],"submitter":["Seifert J"],"funding":["Medizinische Hochschule Hannover (MHH)"],"pubmed_abstract":["<h4>Background</h4>Clinical practice suggests that older adults (i.e., ≥ 65 years of age) experience adverse drug reactions (ADRs) more often than younger patients (i.e., < 65 years of age). ADRs such as falls, extrapyramidal symptoms (EPS), metabolic disorders, sedation, and delirium are particularly worrisome and often associated with psychotropic drugs.<h4>Methods</h4>This observational study investigated the risk for psychotropic drug-related ADRs in older (n = 99,099) and younger adults (n = 363,562) in psychiatric inpatients using data from the German pharmacovigilance program \"Arzneimittelsicherheit in der Psychiatrie\" (AMSP) from 1993-2016. The aim was to assess whether age influenced the risk of specific ADR types and if certain psychotropic drugs posed particular concerns.<h4>Res"],"journal":["Annals of general psychiatry"],"pagination":["47"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575432"],"repository":["biostudies-literature"],"pubmed_title":["Psychotropic drug-induced adverse drug reactions in 462,661 psychiatric inpatients in relation to age: results from a German drug surveillance program from 1993-2016."],"pmcid":["PMC11575432"],"pubmed_authors":["Toto S","Reinhard MA","Glocker C","Greil W","Grohmann R","Bleich S","Seifert J","Erfurth A"],"additional_accession":[]},"is_claimable":false,"name":"Psychotropic drug-induced adverse drug reactions in 462,661 psychiatric inpatients in relation to age: results from a German drug surveillance program from 1993-2016.","description":"<h4>Background</h4>Clinical practice suggests that older adults (i.e., ≥ 65 years of age) experience adverse drug reactions (ADRs) more often than younger patients (i.e., < 65 years of age). ADRs such as falls, extrapyramidal symptoms (EPS), metabolic disorders, sedation, and delirium are particularly worrisome and often associated with psychotropic drugs.<h4>Methods</h4>This observational study investigated the risk for psychotropic drug-related ADRs in older (n = 99,099) and younger adults (n = 363,562) in psychiatric inpatients using data from the German pharmacovigilance program \"Arzneimittelsicherheit in der Psychiatrie\" (AMSP) from 1993-2016. The aim was to assess whether age influenced the risk of specific ADR types and if certain psychotropic drugs posed particular concerns.<h4>Res","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-17T01:08:21.653Z","creation":"2025-04-04T20:39:02.977Z"},"accession":"S-EPMC11575432","cross_references":{"pubmed":["39558338"],"doi":["10.1186/s12991-024-00530-0"]}}