biostudies-literatureUnknown11Manenti I<h4>Introduction</h4>The preservation of locally endangered breeds is essential for maintaining ecosystem services that benefit both society and the environment. Reproductive fitness becomes a crucial consideration in this context. MicroRNAs (miRNAs) are small non-coding RNA molecules that play a key role in post-transcriptional regulation. Typically, they function within the tissues where they are produced. However, when they are released into extracellular fluid, they are referred to as circulating miRNAs (c-miRNAs). C-miRNAs may serve as potential biomarkers, whose profile changes under different physiological states. The purpose of this study is to establish a connection between distinctive variations in the expression of c-miRNAs and specific estrus cycle phases in Frabosana-RoaschinaFrontiers in veterinary science1458463https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575464biostudies-literatureExpression profiles of circulating miRNAs in an endangered Piedmontese sheep breed during the estrus cycle.PMC11575464Macchi EManenti IMiretti SViola IAccornero PToschi PBaratta MAla UMartignani EfalseExpression profiles of circulating miRNAs in an endangered Piedmontese sheep breed during the estrus cycle.<h4>Introduction</h4>The preservation of locally endangered breeds is essential for maintaining ecosystem services that benefit both society and the environment. Reproductive fitness becomes a crucial consideration in this context. MicroRNAs (miRNAs) are small non-coding RNA molecules that play a key role in post-transcriptional regulation. Typically, they function within the tissues where they are produced. However, when they are released into extracellular fluid, they are referred to as circulating miRNAs (c-miRNAs). C-miRNAs may serve as potential biomarkers, whose profile changes under different physiological states. The purpose of this study is to establish a connection between distinctive variations in the expression of c-miRNAs and specific estrus cycle phases in Frabosana-Roaschina2024-01-01T00:00:00Z20242025-04-04T20:38:45.017Z2025-04-04T20:38:45.017ZS-EPMC115754643956418410.3389/fvets.2024.1458463