{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang G"],"funding":["National Natural Science Foundation of China","China Postdoctoral Science Foundation"],"pagination":["19599-19603"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575558"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(46)"],"pubmed_abstract":["Planar-chiral macrocycles play a pivotal role in host-guest chemistry and drug discovery. However, compared with the synthesis of other types of chiral compounds, the asymmetric construction of planar-chiral macrocycles still remains a forbidding challenge. Herein, we report a sequential palladium and N-heterocyclic carbene catalysis to build planar-chiral macrocycles. This protocol features broad scope and good functional group tolerance, and allows a rapid assembling of planar-chiral macrocycles with excellent enantioselectivities."],"journal":["Chemical science"],"pubmed_title":["Pd/NHC sequentially catalyzed atroposelective synthesis of planar-chiral macrocycles."],"pmcid":["PMC11575558"],"funding_grant_id":["21871160","22071130","21672121","2022M721804"],"pubmed_authors":["Yang G","Ji S","Liu S","Wang J","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Pd/NHC sequentially catalyzed atroposelective synthesis of planar-chiral macrocycles.","description":"Planar-chiral macrocycles play a pivotal role in host-guest chemistry and drug discovery. However, compared with the synthesis of other types of chiral compounds, the asymmetric construction of planar-chiral macrocycles still remains a forbidding challenge. Herein, we report a sequential palladium and N-heterocyclic carbene catalysis to build planar-chiral macrocycles. This protocol features broad scope and good functional group tolerance, and allows a rapid assembling of planar-chiral macrocycles with excellent enantioselectivities.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-04T01:45:50.519Z","creation":"2025-04-04T01:45:50.519Z"},"accession":"S-EPMC11575558","cross_references":{"pubmed":["39568868"],"doi":["10.1039/d4sc05482b"]}}