biostudies-literatureYang GNational Natural Science Foundation of ChinaChina Postdoctoral Science Foundation19599-19603https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575558biostudies-literatureUnknown15(46)Planar-chiral macrocycles play a pivotal role in host-guest chemistry and drug discovery. However, compared with the synthesis of other types of chiral compounds, the asymmetric construction of planar-chiral macrocycles still remains a forbidding challenge. Herein, we report a sequential palladium and N-heterocyclic carbene catalysis to build planar-chiral macrocycles. This protocol features broad scope and good functional group tolerance, and allows a rapid assembling of planar-chiral macrocycles with excellent enantioselectivities.Chemical sciencePd/NHC sequentially catalyzed atroposelective synthesis of planar-chiral macrocycles.PMC115755582187116022071130216721212022M721804Yang GJi SLiu SWang JWu XfalsePd/NHC sequentially catalyzed atroposelective synthesis of planar-chiral macrocycles.Planar-chiral macrocycles play a pivotal role in host-guest chemistry and drug discovery. However, compared with the synthesis of other types of chiral compounds, the asymmetric construction of planar-chiral macrocycles still remains a forbidding challenge. Herein, we report a sequential palladium and N-heterocyclic carbene catalysis to build planar-chiral macrocycles. This protocol features broad scope and good functional group tolerance, and allows a rapid assembling of planar-chiral macrocycles with excellent enantioselectivities.2024-01-01T00:00:00Z2024 Nov2025-04-04T01:45:50.519Z2025-04-04T01:45:50.519ZS-EPMC115755583956886810.1039/d4sc05482b