biostudies-literatureXu YBasic and Applied Basic Research Foundation of Guangdong ProvinceNational Natural Science Foundation of China19609-19618https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575559biostudies-literatureUnknown15(46)Biomineralization of a porous metal-organic framework (MOF) shell onto biomacromolecule templates is a burgeoning strategy to construct robust biocatalysts. However, it strongly relies on the interfacial interaction between MOF precursors and enzyme surface, significantly limiting the generalization of this nanotechnology. Herein, we identify polymers that are well-suited for deposition onto target biomacromolecules <i>via</i> supramolecular interactions and introduce a polymer deposition-mediated surface-charge reformation strategy to facilitate the biomineralization of porous MOFs, including ZIF-8, ZIF-90, and ZIF-zni onto enzymes. We investigate nine commercially available polymers to find that those with dense -SO₃H and -COOH groups effectively regulate the surface-charge prChemical scienceA polymer deposition-mediated surface-charge reformation strategy: reversing the MOF biomineralization behavior.PMC115755592023A15150116322024B15150200702210415922174164Yang HHuang SOuyang GTong LHuang WChen GHuang AYi WXu YfalseA polymer deposition-mediated surface-charge reformation strategy: reversing the MOF biomineralization behavior.Biomineralization of a porous metal-organic framework (MOF) shell onto biomacromolecule templates is a burgeoning strategy to construct robust biocatalysts. However, it strongly relies on the interfacial interaction between MOF precursors and enzyme surface, significantly limiting the generalization of this nanotechnology. Herein, we identify polymers that are well-suited for deposition onto target biomacromolecules <i>via</i> supramolecular interactions and introduce a polymer deposition-mediated surface-charge reformation strategy to facilitate the biomineralization of porous MOFs, including ZIF-8, ZIF-90, and ZIF-zni onto enzymes. We investigate nine commercially available polymers to find that those with dense -SO₃H and -COOH groups effectively regulate the surface-charge pr2024-01-01T00:00:00Z2024 Nov2025-04-04T01:45:15.209Z2025-04-04T01:45:15.209ZS-EPMC115755593956893810.1039/d4sc05935b