biostudies-literatureRanjeva SNHLBI NIH HHSNational Institutes of HealthNIH HHSNIGMS NIH HHS31https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575736biostudies-literatureUnknown48(1)Intraoperative cardiopulmonary variables are well-known predictors of postoperative pulmonary complications (PPC), traditionally quantified by median values over the duration of surgery. However, it is unknown whether cardiopulmonary instability, or wider intra-operative variability of the same metrics, is distinctly associated with PPC risk and severity. We leveraged a retrospective cohort of adults (n = 1202) undergoing major non-cardiothoracic surgery. We used multivariable logistic regression to evaluate the association of two outcomes (1)moderate-or-severe PPC and (2)any PPC with two sets of exposure variables- (a)variability of cardiopulmonary metrics (inter-quartile range, IQR) and (b)median intraoperative cardiopulmonary metrics. We compared predictive ability (receiver operating cJournal of medical systemsEffects of Intra-operative Cardiopulmonary Variability On Post-operative Pulmonary Complications in Major Non-cardiac Surgery: A Retrospective Cohort Study.PMC11575736UG3 HL140177T32 GM0075922T32GM007592-41Ruiz RMGiquel JBartels KFernandez-Bustamante ARanjeva SFrendl GSprung JSubramaniam BOdozynski GLee JWNagebretsky AHoule TGupta RAMelo MFVfalseEffects of Intra-operative Cardiopulmonary Variability On Post-operative Pulmonary Complications in Major Non-cardiac Surgery: A Retrospective Cohort Study.Intraoperative cardiopulmonary variables are well-known predictors of postoperative pulmonary complications (PPC), traditionally quantified by median values over the duration of surgery. However, it is unknown whether cardiopulmonary instability, or wider intra-operative variability of the same metrics, is distinctly associated with PPC risk and severity. We leveraged a retrospective cohort of adults (n = 1202) undergoing major non-cardiothoracic surgery. We used multivariable logistic regression to evaluate the association of two outcomes (1)moderate-or-severe PPC and (2)any PPC with two sets of exposure variables- (a)variability of cardiopulmonary metrics (inter-quartile range, IQR) and (b)median intraoperative cardiopulmonary metrics. We compared predictive ability (receiver operating c2024-01-01T00:00:00Z2024 Mar2025-04-04T01:27:57.546Z2025-04-04T01:27:57.546ZS-EPMC115757363848888410.1007/s10916-024-02050-6