biostudies-literatureUnknown19(11)Gao QDespite a growing body of research indicating a link between fasting glucose levels and mortality, the relationship between fasting glucose and all-cause and cancer mortality remains inconsistent. In this study, we used Cox regression and restricted cubic spline models to analyze the association and dose-response relationship between fasting plasma glucose levels and all-cause and cancer mortality in a retrospective cohort based on data from the 2015 health check-ups of residents in Quzhou City. After a mean follow-up of 5.31 years for 148,755 study participants, 10,345 deaths occurred, with an all-cause mortality density of 131.09/10,000 person-years, of which 2,845 were cancer deaths, with a cancer mortality density of 36.05/10,000 person-years. There was a "J" shaped dose-response relatPloS onee0311150https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575760biostudies-literatureFasting plasma glucose levels are associated with all-cause and cancer mortality: A population-based retrospective cohort study.PMC11575760Gao QWang MWang QZhan BGan ZLu DfalseFasting plasma glucose levels are associated with all-cause and cancer mortality: A population-based retrospective cohort study.Despite a growing body of research indicating a link between fasting glucose levels and mortality, the relationship between fasting glucose and all-cause and cancer mortality remains inconsistent. In this study, we used Cox regression and restricted cubic spline models to analyze the association and dose-response relationship between fasting plasma glucose levels and all-cause and cancer mortality in a retrospective cohort based on data from the 2015 health check-ups of residents in Quzhou City. After a mean follow-up of 5.31 years for 148,755 study participants, 10,345 deaths occurred, with an all-cause mortality density of 131.09/10,000 person-years, of which 2,845 were cancer deaths, with a cancer mortality density of 36.05/10,000 person-years. There was a "J" shaped dose-response relat2024-01-01T00:00:00Z20242025-04-04T20:39:02.208Z2025-04-04T20:39:02.208ZS-EPMC115757603956114110.1371/journal.pone.0311150