biostudies-literatureUnknown19(11)Rodriguez-Barrientos CA<h4>Purpose</h4>The shortage of donor corneas limits Bowman layer transplantation for keratoconus. In this study, we evaluate the clinical outcome of porcine anterior lens capsule (xenograft) transplantation in the corneal stroma of a rabbit model as substitute for Bowman layer graft that is used in stromal transplantation for advanced keratoconus.<h4>Methods</h4>Transplantation of porcine anterior lens capsule in the corneal stroma was performed in four New Zealand white rabbits through the creation of a stromal pocket. Corneal transparency, central corneal thickness, and topographic characteristics of corneas were evaluated at different time points: pre- (0) and post- (7, 14, 21, and 28) operative days. Additionally, at the end of the study histopathological findings were evaluated.<h4>RPloS onee0306015https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575790biostudies-literatureIntrastromal graft of anterior lens capsule. A substitute for Bowman layer graft transplantation for keratoconus.PMC11575790Rodriguez-Barrientos CASantaella GTranslateur-Grynspan ABarraquer-Coll CZavala JValdez JEfalseIntrastromal graft of anterior lens capsule. A substitute for Bowman layer graft transplantation for keratoconus.<h4>Purpose</h4>The shortage of donor corneas limits Bowman layer transplantation for keratoconus. In this study, we evaluate the clinical outcome of porcine anterior lens capsule (xenograft) transplantation in the corneal stroma of a rabbit model as substitute for Bowman layer graft that is used in stromal transplantation for advanced keratoconus.<h4>Methods</h4>Transplantation of porcine anterior lens capsule in the corneal stroma was performed in four New Zealand white rabbits through the creation of a stromal pocket. Corneal transparency, central corneal thickness, and topographic characteristics of corneas were evaluated at different time points: pre- (0) and post- (7, 14, 21, and 28) operative days. Additionally, at the end of the study histopathological findings were evaluated.<h4>R2024-01-01T00:00:00Z20242026-07-17T01:05:52.697Z2025-04-04T20:39:03.68ZS-EPMC115757903956116510.1371/journal.pone.0306015