{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liska JP"],"funding":["NEI NIH HHS","NINDS NIH HHS","National Institutes of Health","NIH HHS","Air Force Office of Scientific Research","National Science Foundation"],"pagination":["RP87736"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575896"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["When mice run, activity in their primary visual cortex (V1) is strongly modulated. This observation has altered conceptions of a brain region assumed to be a passive image processor. Extensive work has followed to dissect the circuits and functions of running-correlated modulation. However, it remains unclear whether visual processing in primates might similarly change during locomotion. We therefore measured V1 activity in marmosets while they viewed stimuli on a treadmill. In contrast to mouse, running-correlated modulations of marmoset V1 were small and tended to be slightly suppressive. Population-level analyses revealed trial-to-trial fluctuations of shared gain across V1 in both species, but while strongly correlated with running in mice, gain modulations were smaller and more often "],"journal":["eLife"],"pubmed_title":["Running modulates primate and rodent visual cortex differently."],"pmcid":["PMC11575896"],"funding_grant_id":["BRAIN Initiative U01-UF1NS116377","K99EY032179-02","FA9550-19-1-0357","K99 EY032179","NSC-FO 2123605","UF1 NS116377"],"pubmed_authors":["Muthmann JO","Rowley DP","Yates J","Huk AC","Nguyen TTK","Butts DA","Liska JP"],"additional_accession":[]},"is_claimable":false,"name":"Running modulates primate and rodent visual cortex differently.","description":"When mice run, activity in their primary visual cortex (V1) is strongly modulated. This observation has altered conceptions of a brain region assumed to be a passive image processor. Extensive work has followed to dissect the circuits and functions of running-correlated modulation. However, it remains unclear whether visual processing in primates might similarly change during locomotion. We therefore measured V1 activity in marmosets while they viewed stimuli on a treadmill. In contrast to mouse, running-correlated modulations of marmoset V1 were small and tended to be slightly suppressive. Population-level analyses revealed trial-to-trial fluctuations of shared gain across V1 in both species, but while strongly correlated with running in mice, gain modulations were smaller and more often ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-04T20:38:25.546Z","creation":"2025-04-04T20:38:25.546Z"},"accession":"S-EPMC11575896","cross_references":{"pubmed":["39560660"],"doi":["10.7554/eLife.87736"]}}