biostudies-literatureUnknown14(1)Tang XUrinary incontinence (UI) in females is a prevailing condition that affects individuals across various age groups and is not limited to older females. The presence of serum alpha-Klotho (α-klotho) serves as a reliable biomarker to indicate the effects of antiaging. Nevertheless, the scientific research on the association between α-klotho and UI remains limited. Therefore, the purpose of this study is to investigate and evaluate the connection between α-klotho levels and the UI among females in the US. We utilized data from the National Health and Nutrition Examination Survey 2007-2016 to investigate the potential connection between α-klotho levels and the UI among females aged 40 to 79. Weighted linear regression models and sensitivity tests were conducted to explore the correlation. 2628 Scientific reports28667https://www.ebi.ac.uk/biostudies/studies/S-EPMC11577013biostudies-literatureThe relationship between serum alpha-klotho levels and urinary incontinence in middle-aged and older females: insights from NHANES.PMC11577013Du RYang LLiang HChen ZHe WYang CTang XSong YfalseThe relationship between serum alpha-klotho levels and urinary incontinence in middle-aged and older females: insights from NHANES.Urinary incontinence (UI) in females is a prevailing condition that affects individuals across various age groups and is not limited to older females. The presence of serum alpha-Klotho (α-klotho) serves as a reliable biomarker to indicate the effects of antiaging. Nevertheless, the scientific research on the association between α-klotho and UI remains limited. Therefore, the purpose of this study is to investigate and evaluate the connection between α-klotho levels and the UI among females in the US. We utilized data from the National Health and Nutrition Examination Survey 2007-2016 to investigate the potential connection between α-klotho levels and the UI among females aged 40 to 79. Weighted linear regression models and sensitivity tests were conducted to explore the correlation. 2628 2024-01-01T00:00:00Z2024 Nov2025-04-18T17:08:51.982Z2025-04-07T04:41:07.316ZS-EPMC115770133956262510.1038/s41598-024-80231-6