{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bartens MC"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["136-149"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11577332"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(6-8)"],"pubmed_abstract":["The role of macrophage (MØ) cellular metabolism and reprogramming during TB infection is of great interest due to the influence of <i>Mycobacterium</i> spp. on MØ bioenergetics. Recent studies have shown that <i>M. tuberculosis</i> induces a TLR2-dependent shift towards aerobic glycolysis, comparable to the established LPS induced pro-inflammatory M1 MØ polarisation. Distinct differences in the metabolic profile of murine and human MØ indicates species-specific differences in bioenergetics. So far, studies examining the metabolic potential of bovine MØ are lacking, thus the basic bioenergetics of bovine and human MØ were explored in response to a variety of innate immune stimuli. Cellular energy metabolism kinetics were measured concurrently for both species on a Seahorse XFe96 platform to"],"journal":["Innate immunity"],"pubmed_title":["Respiratory bioenergetics is enhanced in human, but not bovine macrophages after exposure to &lt;i&gt;M. bovis&lt;/i&gt; PPD: Exploratory insights into overall similar Cellular Metabolic Profiles."],"pmcid":["PMC11577332"],"funding_grant_id":["BB/P008461/1","BB/N004590/1"],"pubmed_authors":["Gibson AJ","Werling D","Willcocks S","Bartens MC"],"additional_accession":[]},"is_claimable":false,"name":"Respiratory bioenergetics is enhanced in human, but not bovine macrophages after exposure to &lt;i&gt;M. bovis&lt;/i&gt; PPD: Exploratory insights into overall similar Cellular Metabolic Profiles.","description":"The role of macrophage (MØ) cellular metabolism and reprogramming during TB infection is of great interest due to the influence of <i>Mycobacterium</i> spp. on MØ bioenergetics. Recent studies have shown that <i>M. tuberculosis</i> induces a TLR2-dependent shift towards aerobic glycolysis, comparable to the established LPS induced pro-inflammatory M1 MØ polarisation. Distinct differences in the metabolic profile of murine and human MØ indicates species-specific differences in bioenergetics. So far, studies examining the metabolic potential of bovine MØ are lacking, thus the basic bioenergetics of bovine and human MØ were explored in response to a variety of innate immune stimuli. Cellular energy metabolism kinetics were measured concurrently for both species on a Seahorse XFe96 platform to","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T01:15:38.337Z","creation":"2025-04-04T01:15:38.337Z"},"accession":"S-EPMC11577332","cross_references":{"pubmed":["39563509"],"doi":["10.1177/17534259241296630"]}}