{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Silva FLT"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","Fundação de Amparo à Pesquisa do Estado de São Paulo","PRONON"],"pagination":["1428"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11577672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Pediatric sarcomas present heterogeneous morphology, genetics and clinical behavior posing a challenge for an accurate diagnosis. DNA methylation is an epigenetic modification that coordinates chromatin structure and regulates gene expression, determining cell type and function. DNA methylation-based tumor profiling classifier for sarcomas (known as sarcoma classifier) from the German Cancer Research Center (Deutsches Krebsforschungszentrum) was applied to 122 pediatric sarcomas referred to a reference pediatric oncology hospital. The classifiers reported 88.5% of agreement between histopathological and molecular classification confirming the initial diagnosis of all osteosarcomas and Ewing sarcomas. The Ewing-like sarcomas were reclassified into sarcomas with BCOR or CIC alterations, late"],"journal":["BMC cancer"],"pubmed_title":["Classification of pediatric soft and bone sarcomas using DNA methylation-based profiling."],"pmcid":["PMC11577672"],"funding_grant_id":["SIPAR 25000.211368/2019-41","2021/06782-7","2022/04781-6","311141/2021-8","SIPAR 25000.012259/2019-42"],"pubmed_authors":["Euzebio MF","Silva FLT","Franco MT","Zenatti PP","Jotta PY","Pereira LH","Ruas JS","Lucon DR","Cardinalli IA","Junqueira T","Maschietto M","Cassone AE"],"additional_accession":[]},"is_claimable":false,"name":"Classification of pediatric soft and bone sarcomas using DNA methylation-based profiling.","description":"Pediatric sarcomas present heterogeneous morphology, genetics and clinical behavior posing a challenge for an accurate diagnosis. DNA methylation is an epigenetic modification that coordinates chromatin structure and regulates gene expression, determining cell type and function. DNA methylation-based tumor profiling classifier for sarcomas (known as sarcoma classifier) from the German Cancer Research Center (Deutsches Krebsforschungszentrum) was applied to 122 pediatric sarcomas referred to a reference pediatric oncology hospital. The classifiers reported 88.5% of agreement between histopathological and molecular classification confirming the initial diagnosis of all osteosarcomas and Ewing sarcomas. The Ewing-like sarcomas were reclassified into sarcomas with BCOR or CIC alterations, late","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-26T01:56:34.189Z","creation":"2025-04-06T10:18:52.175Z"},"accession":"S-EPMC11577672","cross_references":{"pubmed":["39567898"],"doi":["10.1186/s12885-024-13159-9"]}}