{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li FX"],"funding":["Health Research Project of Hunan Provincial Health Commission","National Key Research & Development Program","The Health Research Project in Hunan Province","National Key Research & Development Program","the Natural Science Foundation of Hunan Province","National Clinical Key Specialties Major Research Projects","the Scientific Research Launch Project for new employees of the Second Xiangya Hospital of Central South University","the National Natural Science Foundation of China"],"pagination":["723"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11577949"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Cold temperatures have been shown to slow skin wound healing. However, the specific mechanisms underlying cold-induced impairment of wound healing remain unclear. Here, we demonstrate that small extracellular vesicles derived from cold-exposed mouse plasma (CT-sEVs) decelerate re-epithelialization, increase scar width, and weaken angiogenesis. CT-sEVs are enriched with miRNAs involved in the regulation of wound healing-related biological processes. Functional assays revealed that miR-423-3p, enriched in CT-sEVs, acts as a critical mediator in cold-induced impairment of angiogenic responses and poor wound healing by inhibiting phosphatase and poly(A) binding protein cytoplasmic 1 (PABPC1). These findings indicate that cold delays wound healing via miR-423-3p in plasma-derived sEVs through t"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Mechanism of cold exposure delaying wound healing in mice."],"pmcid":["PMC11577949"],"funding_grant_id":["82370892","7673","W20243019","2022JJ40721","2021YFC2501701","Z2023026","20231696"],"pubmed_authors":["Zheng MH","Liu JJ","Cao YC","Yuan LQ","Lin X","Tang KX","Duan JY","Li FX","Xu F","Wu YL","He SY","Li YH","Wu F","Shan SK","Chen X","Cui RR","Guo B","Li CC","Wu YY","Lei LM"],"additional_accession":[]},"is_claimable":false,"name":"Mechanism of cold exposure delaying wound healing in mice.","description":"Cold temperatures have been shown to slow skin wound healing. However, the specific mechanisms underlying cold-induced impairment of wound healing remain unclear. Here, we demonstrate that small extracellular vesicles derived from cold-exposed mouse plasma (CT-sEVs) decelerate re-epithelialization, increase scar width, and weaken angiogenesis. CT-sEVs are enriched with miRNAs involved in the regulation of wound healing-related biological processes. Functional assays revealed that miR-423-3p, enriched in CT-sEVs, acts as a critical mediator in cold-induced impairment of angiogenic responses and poor wound healing by inhibiting phosphatase and poly(A) binding protein cytoplasmic 1 (PABPC1). These findings indicate that cold delays wound healing via miR-423-3p in plasma-derived sEVs through t","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-19T14:35:36.445Z","creation":"2025-04-19T14:35:36.445Z"},"accession":"S-EPMC11577949","cross_references":{"pubmed":["39568002"],"doi":["10.1186/s12951-024-03009-y"]}}