{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Koyama Y"],"funding":["Singapore Institute for Clinical Sciences","Agency for Science, Technology and Research","National Research Foundation Singapore","National Medical Research Council"],"pubmed_abstract":["<h4>Background</h4>Harsh parenting in early childhood is related to offspring's adverse behavioral outcomes. Due to the scarcity of longitudinal neuroimaging data, few studies have explored the neurobiological underpinnings of this association, focusing on within-person variability. This study examined the temporal associations among harsh parenting, later behavioral problems, and the developmental trajectories of amygdala volume and amygdala resting-state functional connectivity (RSFC) profiles, using longitudinal neuroimaging data.<h4>Methods</h4>The study was embedded in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. T1-weighted (296 children, 642 scans) and resting-state functional scans (256 children, 509 scans) were collected at ages 4.5, 6, 7.5, and 10.5 years."],"journal":["Psychological medicine"],"pagination":["1-12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11578908"],"repository":["biostudies-literature"],"pubmed_title":["Harsh parenting, amygdala functional connectivity changes across childhood, and behavioral problems."],"pmcid":["PMC11578908"],"funding_grant_id":["NMRC/TCR/012-NUHS/2014","Brain-Body Initiative, iGrants call ID #21718","MOH-001273-00"],"pubmed_authors":["Meaney M","Chan SY","Sudo M","Koyama Y","Kyeong Y","Setoh P","Tan AP","Tiemeier H","Huang P"],"additional_accession":[]},"is_claimable":false,"name":"Harsh parenting, amygdala functional connectivity changes across childhood, and behavioral problems.","description":"<h4>Background</h4>Harsh parenting in early childhood is related to offspring's adverse behavioral outcomes. Due to the scarcity of longitudinal neuroimaging data, few studies have explored the neurobiological underpinnings of this association, focusing on within-person variability. This study examined the temporal associations among harsh parenting, later behavioral problems, and the developmental trajectories of amygdala volume and amygdala resting-state functional connectivity (RSFC) profiles, using longitudinal neuroimaging data.<h4>Methods</h4>The study was embedded in the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. T1-weighted (296 children, 642 scans) and resting-state functional scans (256 children, 509 scans) were collected at ages 4.5, 6, 7.5, and 10.5 years.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-22T02:41:28.506Z","creation":"2025-04-05T20:28:44.584Z"},"accession":"S-EPMC11578908","cross_references":{"pubmed":["39479759"],"doi":["10.1017/S003329172400196X"]}}