biostudies-literatureWeese-Mayer DENHLBI NIH HHS1060-1069https://www.ebi.ac.uk/biostudies/studies/S-EPMC11580183biostudies-literatureUnknown95(4)<h4>Background</h4>In extremely preterm infants, persistence of cardioventilatory events is associated with long-term morbidity. Therefore, the objective was to characterize physiologic growth curves of apnea, periodic breathing, intermittent hypoxemia, and bradycardia in extremely preterm infants during the first few months of life.<h4>Methods</h4>The Prematurity-Related Ventilatory Control study included 717 preterm infants <29 weeks gestation. Waveforms were downloaded from bedside monitors with a novel sharing analytics strategy utilized to run software locally, with summary data sent to the Data Coordinating Center for compilation.<h4>Results</h4>Apnea, periodic breathing, and intermittent hypoxemia events rose from day 3 of life then fell to near-resolution by 8-12 weeks of age. ApnePediatric researchMaturation of cardioventilatory physiological trajectories in extremely preterm infants.PMC11580183U01 HL133708U01 HL133704U01 HL133700U01 HL133689U01 HL133536U01 HL133643Qiu JAguilar ACBancalari ELonergan EKMoorman JRMartin RJIndic PCarlo WALaney DHibbs AMSchott ADennery PACarroll JLKrishnamurthi NFadl-Alla AZimmet AMFairchild KDNakhmani ATravers CPLake DEAmbalavanan NRand CMClaure NZadell AHamvas AWeese-Mayer DEPrematurity-Related Ventilatory Control (Pre-Vent) InvestigatorsKemp JSDi Fiore JMKrahn KNHoffmann JRatcliffe SJDormishian AfalseMaturation of cardioventilatory physiological trajectories in extremely preterm infants.<h4>Background</h4>In extremely preterm infants, persistence of cardioventilatory events is associated with long-term morbidity. Therefore, the objective was to characterize physiologic growth curves of apnea, periodic breathing, intermittent hypoxemia, and bradycardia in extremely preterm infants during the first few months of life.<h4>Methods</h4>The Prematurity-Related Ventilatory Control study included 717 preterm infants <29 weeks gestation. Waveforms were downloaded from bedside monitors with a novel sharing analytics strategy utilized to run software locally, with summary data sent to the Data Coordinating Center for compilation.<h4>Results</h4>Apnea, periodic breathing, and intermittent hypoxemia events rose from day 3 of life then fell to near-resolution by 8-12 weeks of age. Apne2024-01-01T00:00:00Z2024 Mar2026-06-02T03:52:15.264Z2025-04-06T22:45:35.308ZS-EPMC115801833785784810.1038/s41390-023-02839-0