biostudies-literatureXu MLife Sciences Division, Army Research OfficeNational Science Foundation1598-1604https://www.ebi.ac.uk/biostudies/studies/S-EPMC11580386biostudies-literatureUnknown13(11)The synthesis and application of multifunctional diazirine-containing polymers for on-demand cross-linking of unfunctionalized commodity polymers through C-H bond insertion is demonstrated. While small-molecule diazirine cross-linkers have seen important applications such as plastic compatibilization and photopatterning, the high degree of functionalization of polymer-based diazirine cross-linkers offers promise for enhanced compatibility based on polymer blending and increased efficiency due to controllable multivalency. As a demonstrative example, unfunctionalized linear poly(<i>n</i>-butyl acrylate) (P<i>n</i>BA) can be cross-linked using various polymeric cross-linkers with diazirine contents as low as 0.8 wt % in 1 min under photochemical conditions. With gel fractions up to 95%, tunaACS macro lettersEfficient Cross-Linking through C-H Bond Insertion of Unfunctionalized Commodity Materials Using Diazirine-Containing Polymers.PMC11580386DMR-1933487W911NF-19-D-0001Xu MBeech HKGetty PTHuang BHawker CJUruena JMfalseEfficient Cross-Linking through C-H Bond Insertion of Unfunctionalized Commodity Materials Using Diazirine-Containing Polymers.The synthesis and application of multifunctional diazirine-containing polymers for on-demand cross-linking of unfunctionalized commodity polymers through C-H bond insertion is demonstrated. While small-molecule diazirine cross-linkers have seen important applications such as plastic compatibilization and photopatterning, the high degree of functionalization of polymer-based diazirine cross-linkers offers promise for enhanced compatibility based on polymer blending and increased efficiency due to controllable multivalency. As a demonstrative example, unfunctionalized linear poly(<i>n</i>-butyl acrylate) (P<i>n</i>BA) can be cross-linked using various polymeric cross-linkers with diazirine contents as low as 0.8 wt % in 1 min under photochemical conditions. With gel fractions up to 95%, tuna2024-01-01T00:00:00Z2024 Nov2025-04-26T01:54:37.748Z2025-04-06T10:18:40.401ZS-EPMC115803863951354510.1021/acsmacrolett.4c00675