{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rao C"],"funding":["Army Medical University Foundations","MOST | National Natural Science Foundation of China (NSFC)","National Natural Science Foundation of China","National Natural Science Foundation of China (NSFC)","MOST | National Natural Science Foundation of China"],"pagination":["e0045324"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11580396"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(11)"],"pubmed_abstract":["Melioidosis is a serious infectious disease caused by the Gram-negative bacterium <i>Burkholderia pseudomallei</i>. Recently, Rab32-dependent immune vesicles emerge as a critical defense pathway to restrict the intracellular <i>B. pseudomallei</i>. However, <i>B. pseudomallei</i> can evade host immune vesicles and survive in the cytoplasm, although this mechanism is not well understood. In this study, we found Rab32-dependent vesicles could effectively combat <i>B. pseudomallei</i> infection, but not all intracellular <i>B. pseudomallei</i> were encapsulated in Rab32-positive vesicles. To explore how <i>B. pseudomallei</i> counteracted the Rab32-dependent defense pathway, transcriptomic profiling of <i>B. pseudomallei</i> was performed to characterize the response dynamics during infection"],"journal":["mSphere"],"pubmed_title":["<i>Burkholderia pseudomallei</i> BopE suppresses the Rab32-dependent defense pathway to promote its intracellular replication and virulence."],"pmcid":["PMC11580396"],"funding_grant_id":["2021-2018-098,2020XQN06","82402640","32270190,82272350"],"pubmed_authors":["Wen Y","Liao Y","Yan J","Huang J","Hu Z","Nan D","Wu P","Zheng S","Li Q","Wang L","Liu W","Rao C","Zhang Z","Wang S","Yao C","Mao X","Qiao J"],"additional_accession":[]},"is_claimable":false,"name":"<i>Burkholderia pseudomallei</i> BopE suppresses the Rab32-dependent defense pathway to promote its intracellular replication and virulence.","description":"Melioidosis is a serious infectious disease caused by the Gram-negative bacterium <i>Burkholderia pseudomallei</i>. Recently, Rab32-dependent immune vesicles emerge as a critical defense pathway to restrict the intracellular <i>B. pseudomallei</i>. However, <i>B. pseudomallei</i> can evade host immune vesicles and survive in the cytoplasm, although this mechanism is not well understood. In this study, we found Rab32-dependent vesicles could effectively combat <i>B. pseudomallei</i> infection, but not all intracellular <i>B. pseudomallei</i> were encapsulated in Rab32-positive vesicles. To explore how <i>B. pseudomallei</i> counteracted the Rab32-dependent defense pathway, transcriptomic profiling of <i>B. pseudomallei</i> was performed to characterize the response dynamics during infection","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-03T01:07:47.483Z","creation":"2025-04-04T12:00:29.891Z"},"accession":"S-EPMC11580396","cross_references":{"pubmed":["39431830"],"doi":["10.1128/msphere.00453-24"]}}