{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schmidt M"],"funding":["Bundesministerium für Bildung und Forschung","Deutsche Forschungsgemeinschaft","Universitätsklinikum RWTH Aachen","Medizinische Fakultät, RWTH Aachen University","Else Kröner-Fresenius-Stiftung"],"pagination":["164"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11580436"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment and play a critical role in cancer progression. Numerous studies have identified significant molecular differences between CAFs and normal tissue-associated fibroblasts (NAFs). In this study, we isolated CAFs and NAFs from liver tumors and conducted a comprehensive analysis of their DNA methylation profiles, integrating our finding with data from studies on other cancer types.<h4>Results</h4>Our analysis revealed that several CAF samples exhibited aberrant DNA methylation patterns, which corresponded with altered gene expression levels. Notably, DNA methylation at liver CAF-specific CpG sites was linked to survival outcomes in liver cancer datasets. An integrative analysis using p"],"journal":["Clinical epigenetics"],"pubmed_title":["Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer."],"pmcid":["PMC11580436"],"funding_grant_id":["FibroMap Corsortia","ForTra gGmbH PrickMe","SFB 1506/1","IZKF O3-3","WA 1706/12-2","WA1706/14-1","GE 2811/4-1 within CRU344/417911533","WA1706/11-1","363055819/GRK2415"],"pubmed_authors":["Schmidt M","Costa IG","Cramer T","Wagner W","Maie T"],"additional_accession":[]},"is_claimable":false,"name":"Cancer-associated fibroblasts reveal aberrant DNA methylation across different types of cancer.","description":"<h4>Background</h4>Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment and play a critical role in cancer progression. Numerous studies have identified significant molecular differences between CAFs and normal tissue-associated fibroblasts (NAFs). In this study, we isolated CAFs and NAFs from liver tumors and conducted a comprehensive analysis of their DNA methylation profiles, integrating our finding with data from studies on other cancer types.<h4>Results</h4>Our analysis revealed that several CAF samples exhibited aberrant DNA methylation patterns, which corresponded with altered gene expression levels. Notably, DNA methylation at liver CAF-specific CpG sites was linked to survival outcomes in liver cancer datasets. An integrative analysis using p","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-04T01:21:29.508Z","creation":"2025-04-04T01:21:29.508Z"},"accession":"S-EPMC11580436","cross_references":{"pubmed":["39567960"],"doi":["10.1186/s13148-024-01783-y"]}}