{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hourigan D"],"funding":["European Research Council","Science Foundation Ireland (SFI)","EC | H2020 | PRIORITY 'Excellent science' | H2020 Marie Skłodowska-Curie Actions (MSCA)"],"pagination":["e0029824"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11580447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["206(11)"],"pubmed_abstract":["Leaderless bacteriocins are a unique class of bacteriocins that possess antimicrobial activity after translation and have few cases of documented resistance. Aureocin A53 and lacticin Q are considered two of the most well-studied leaderless bacteriocins. Here, we used <i>in silico</i> genome mining to search for novel aureocin A53-like leaderless bacteriocins in GenBank and MGnify. We identified 757 core peptides across 430 genomes with 75 species found currently without characterized leaderless bacteriocin production. These include putative novel species containing bacteriocin gene clusters (BGCs) from the genera <i>Streptomyces</i> (sp. NBC_00237) and <i>Agrococcus</i> (sp. SL85). To date, all characterized leaderless bacteriocins have been found within the phylum Bacillota, but this stu"],"journal":["Journal of bacteriology"],"pubmed_title":["Discovery and synthesis of leaderless bacteriocins from the Actinomycetota."],"pmcid":["PMC11580447"],"funding_grant_id":["SFI/ 12/RC/2273_P2","101054719","101034270"],"pubmed_authors":["Miceli de Farias F","Hill C","Ross RP","O'Connor PM","Hourigan D"],"additional_accession":[]},"is_claimable":false,"name":"Discovery and synthesis of leaderless bacteriocins from the Actinomycetota.","description":"Leaderless bacteriocins are a unique class of bacteriocins that possess antimicrobial activity after translation and have few cases of documented resistance. Aureocin A53 and lacticin Q are considered two of the most well-studied leaderless bacteriocins. Here, we used <i>in silico</i> genome mining to search for novel aureocin A53-like leaderless bacteriocins in GenBank and MGnify. We identified 757 core peptides across 430 genomes with 75 species found currently without characterized leaderless bacteriocin production. These include putative novel species containing bacteriocin gene clusters (BGCs) from the genera <i>Streptomyces</i> (sp. NBC_00237) and <i>Agrococcus</i> (sp. SL85). To date, all characterized leaderless bacteriocins have been found within the phylum Bacillota, but this stu","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-05-27T22:28:21.425Z","creation":"2025-04-21T21:48:44.981Z"},"accession":"S-EPMC11580447","cross_references":{"pubmed":["39404462"],"doi":["10.1128/jb.00298-24"]}}