{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morgan DM"],"funding":["NCI NIH HHS"],"pagination":["eadi3487"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11580689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(99)"],"pubmed_abstract":["Immune checkpoint blockade (ICB) enhances T cell responses against cancer, leading to long-term survival in a fraction of patients. CD8<sup>+</sup> T cell differentiation in response to chronic antigen stimulation is highly complex, and it remains unclear precisely which T cell differentiation states at which anatomic sites are critical for the response to ICB. We identified an intermediate-exhausted population in the white pulp of the spleen that underwent substantial expansion in response to ICB and gave rise to tumor-infiltrating clonotypes. Increased systemic antigen redirected differentiation of this population toward a more circulatory exhausted KLR state, whereas a lack of cross-presented tumor antigen reduced its differentiation in the spleen. An analogous population of exhausted K"],"journal":["Science immunology"],"pubmed_title":["Expansion of tumor-reactive CD8&lt;sup&gt;+&lt;/sup&gt; T cell clonotypes occurs in the spleen in response to immune checkpoint blockade."],"pmcid":["PMC11580689"],"funding_grant_id":["P30 CA014051","R37 CA273819"],"pubmed_authors":["Zagorulya M","Love JC","Spranger S","Dinter T","Horton BL","Bhandarkar V","Van R","Morgan DM"],"additional_accession":[]},"is_claimable":false,"name":"Expansion of tumor-reactive CD8&lt;sup&gt;+&lt;/sup&gt; T cell clonotypes occurs in the spleen in response to immune checkpoint blockade.","description":"Immune checkpoint blockade (ICB) enhances T cell responses against cancer, leading to long-term survival in a fraction of patients. CD8<sup>+</sup> T cell differentiation in response to chronic antigen stimulation is highly complex, and it remains unclear precisely which T cell differentiation states at which anatomic sites are critical for the response to ICB. We identified an intermediate-exhausted population in the white pulp of the spleen that underwent substantial expansion in response to ICB and gave rise to tumor-infiltrating clonotypes. Increased systemic antigen redirected differentiation of this population toward a more circulatory exhausted KLR state, whereas a lack of cross-presented tumor antigen reduced its differentiation in the spleen. An analogous population of exhausted K","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2025-04-04T01:21:27.364Z","creation":"2025-04-04T01:21:27.364Z"},"accession":"S-EPMC11580689","cross_references":{"pubmed":["39270006"],"doi":["10.1126/sciimmunol.adi3487"]}}