{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(6)"],"submitter":["Muehlberg C"],"pubmed_abstract":["Successful motor skill acquisition requires the dynamic interaction of multiple brain regions, with the striatum playing a critical role in this network. Animal studies suggest that dopaminergic mechanisms are involved in the regulation of motor learning-associated striatal plasticity. In humans, however, the contribution of nigrostriatal dopaminergic transmission to motor learning remains elusive beyond its well-characterized role in initiation and fluent execution of movements. In this prospective observational study, we investigated motor sequence learning in individuals who had undergone <sup>123</sup>I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography for the differential diagnosis of Parkinson's disease (<i>n</i> = 41) and age-mat"],"journal":["Brain communications"],"pagination":["fcae409"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11582004"],"repository":["biostudies-literature"],"pubmed_title":["Motor learning is modulated by dopamine availability in the sensorimotor putamen."],"pmcid":["PMC11582004"],"pubmed_authors":["Rumpf JJ","Rullmann M","Muehlberg C","Wawrzyniak M","Fricke C","Goerg S","Classen J","Hesse S","Sabri O"],"additional_accession":[]},"is_claimable":false,"name":"Motor learning is modulated by dopamine availability in the sensorimotor putamen.","description":"Successful motor skill acquisition requires the dynamic interaction of multiple brain regions, with the striatum playing a critical role in this network. Animal studies suggest that dopaminergic mechanisms are involved in the regulation of motor learning-associated striatal plasticity. In humans, however, the contribution of nigrostriatal dopaminergic transmission to motor learning remains elusive beyond its well-characterized role in initiation and fluent execution of movements. In this prospective observational study, we investigated motor sequence learning in individuals who had undergone <sup>123</sup>I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography for the differential diagnosis of Parkinson's disease (<i>n</i> = 41) and age-mat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T01:32:32.929Z","creation":"2025-04-04T01:32:32.929Z"},"accession":"S-EPMC11582004","cross_references":{"pubmed":["39584157"],"doi":["10.1093/braincomms/fcae409"]}}