biostudies-literatureUnknown6(6)Muehlberg CSuccessful motor skill acquisition requires the dynamic interaction of multiple brain regions, with the striatum playing a critical role in this network. Animal studies suggest that dopaminergic mechanisms are involved in the regulation of motor learning-associated striatal plasticity. In humans, however, the contribution of nigrostriatal dopaminergic transmission to motor learning remains elusive beyond its well-characterized role in initiation and fluent execution of movements. In this prospective observational study, we investigated motor sequence learning in individuals who had undergone ¹²³I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography for the differential diagnosis of Parkinson's disease (<i>n</i> = 41) and age-matBrain communicationsfcae409https://www.ebi.ac.uk/biostudies/studies/S-EPMC11582004biostudies-literatureMotor learning is modulated by dopamine availability in the sensorimotor putamen.PMC11582004Rumpf JJRullmann MMuehlberg CWawrzyniak MFricke CGoerg SClassen JHesse SSabri OfalseMotor learning is modulated by dopamine availability in the sensorimotor putamen.Successful motor skill acquisition requires the dynamic interaction of multiple brain regions, with the striatum playing a critical role in this network. Animal studies suggest that dopaminergic mechanisms are involved in the regulation of motor learning-associated striatal plasticity. In humans, however, the contribution of nigrostriatal dopaminergic transmission to motor learning remains elusive beyond its well-characterized role in initiation and fluent execution of movements. In this prospective observational study, we investigated motor sequence learning in individuals who had undergone ¹²³I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane single-photon emission computed tomography for the differential diagnosis of Parkinson's disease (<i>n</i> = 41) and age-mat2024-01-01T00:00:00Z20242025-04-04T01:32:32.929Z2025-04-04T01:32:32.929ZS-EPMC115820043958415710.1093/braincomms/fcae409