biostudies-literatureLi MNingbo Top Medical and Health Research ProgramNingbo Key Research and Development Program1328https://www.ebi.ac.uk/biostudies/studies/S-EPMC11583402biostudies-literatureUnknown24(1)<h4>Background</h4>The carpal tunnel syndrome (CTS) caused by atypical infection is a therapeutic and diagnostic challenge. Atypical clinical presentations often lead to misdiagnosis and incorrect therapy.<h4>Case presentation</h4>This article reports a case of deep infection leading to CTS manifestations. A male patient was admitted for numbness and pain of the left hand. Left carpal tunnel release, median nerve decompression with synovial resection were performed. Inflamed synovium and effusion were submitted for bacterial culture and metagenomic next-generation sequencing (mNGS). The etiologic agent was identified as Arthrinium phaeospermum and the patient recovered after surgical debridement and 10 months of therapy.<h4>Conclusions</h4>Diagnosis of mycotic infection of the hand is chalBMC infectious diseasesThe carpal tunnel syndrome caused by Arthrinium phaeospermum infection: first case report and literature review.PMC11583402No.2022020506)No. 2022Z146Li XLi YLi MfalseThe carpal tunnel syndrome caused by Arthrinium phaeospermum infection: first case report and literature review.<h4>Background</h4>The carpal tunnel syndrome (CTS) caused by atypical infection is a therapeutic and diagnostic challenge. Atypical clinical presentations often lead to misdiagnosis and incorrect therapy.<h4>Case presentation</h4>This article reports a case of deep infection leading to CTS manifestations. A male patient was admitted for numbness and pain of the left hand. Left carpal tunnel release, median nerve decompression with synovial resection were performed. Inflamed synovium and effusion were submitted for bacterial culture and metagenomic next-generation sequencing (mNGS). The etiologic agent was identified as Arthrinium phaeospermum and the patient recovered after surgical debridement and 10 months of therapy.<h4>Conclusions</h4>Diagnosis of mycotic infection of the hand is chal2024-01-01T00:00:00Z2024 Nov2025-04-26T01:53:28.069Z2025-04-06T10:20:17.684ZS-EPMC115834023957399310.1186/s12879-024-10232-3