{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Gomes-Silva J"],"pubmed_abstract":["Nucleic acid amplification tests (NAATs) greatly enhance the capacity to identify the etiology of pediatric complicated pneumonia. However, the use of pneumococcal conjugate vaccines could reduce the importance of Streptococcus pneumoniae in pediatric complicated pneumonia with the potential emergence of other bacterial agents. Using an expanded NAAT in culture negative pleural fluid or empyema samples collected in 2010-2024 (n = 554) in Portugal, we show that S. pneumoniae remains the most frequent agent despite decades of pneumococcal conjugate vaccine use and the COVID-19 pandemic. A rebound in pediatric complicated pneumonia occurred post-pandemic, including a rise in cases by Streptococcus pyogenes and Haemophilus influenzae. Empiric therapy of pediatric complicated pneumonia should s"],"journal":["Pneumonia (Nathan Qld.)"],"pagination":["26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11587768"],"repository":["biostudies-literature"],"pubmed_title":["Pneumococci remain the main cause of complicated pediatric pneumonia in the post-pandemic era despite extensive pneumococcal vaccine use."],"pmcid":["PMC11587768"],"pubmed_authors":["Teixeira AL","Alves V","Fraga S","Teixeira A","Costa A","Aguiar A","Gouveia Pestana P","Guerreiro N","Chantre O","Loureiro H","Iglesias MC","Costa H","Lopes V","Rodrigues F","Virtuoso MJ","Rodrigues G","Rodrigues H","Semedo R","Aliyeva E","Rego de Sousa MJ","Peres I","Lopes P","Marcelo F","Pessanha MA","Lucas M","Marcelo C","Kruptsala N","Tomas MJ","Rodrigues V","Lopes F","Reis T","Calado E","Fortunato F","Falcao MP","Banza S","Cristovam E","Schafer S","Bernardo A","Fonseca AB","Selaru A","Cunha M","Mendes V","Gaspar E","Silva-Costa C","Ramirez M","Fenandes A","Nunes F","Moreira D","Rebelo M","Seves G","Tavares M","Silva M","Carneiro L","Marrao G","Nogueira Martins L","Silva F","Moreira E","Cabral M","Martins N","Seruca M","Miguel B","Lourenco I","Tome T","Santos S","Mota Preto C","Faria C","Gomes D","Sampaio SF","Cruz C","Faria J","Brandao M","Novais C","Cruz H","Correia AB","Lima S","Veiga E","Morais T","Ferreira S","Portuguese Study Group of Invasive Pneumococcal Disease of the Pediatric Infectious Disease Society","Ferreira R","Morais R","Boaventura L","Pedrosa A","Prata F","Bernardo J","Afonso MA","Sousa A","Silva MF","Lourinha M","Chaves C","Bettencourt Viana M","Pereira F","Nicolau M","Ferreira C","Dinis MJ","Ferreira M","Pereira M","Arosa S","Cravo Roxo I","Coutinho A","Novais N","Fonseca F","Tomaz M","Resende AF","Fidalgo C","Braga A","Calado Nunes J","Zarcos MM","Costa Alves M","Abreu G","Pontes C","Vicente F","Daniel I","Mota Vieira AP","Fardilha M","Vicente A","Pinho MD","Pereira P","Camacho B","Tapadinhas I","Nunes MAS","Monge I","Aires S","Friaes A","Almeida S","Marques S","Read MA","Portuguese Group for the Study of Streptococcal Infections","Didelet C","Macedo H","Diaz R","Vieira S","Flores P","Lameirao A","Ribeiro M","Portugal C","Vieira M","Correia P","Brito I","Pinto M","Pina T","Guedes M","Giao M","Jesus A","Toscano C","Resende C","Melo-Cristino J","Azevedo M","Ribeiro RT","Carvalho P","Goncalves H","Gomes-Silva J","Lito LM","Amantegui P","Goncalves E","Faustino A","Marta J","Cunha J","Marques J","Braganca C","Cunha F","Diogo J","Marques L","Goncalves L","Castro AP","Menezes MF","Monteiro C","Gouveia C","Mota Freitas J","Selada J","Vale I","Salgado A","Carvalho I","Fontes I","Massa R","Oliveira L","Oliveira M","Leite C","Franco J","Duarte J","Calle M","Monteiro M","Oliveira H","Monteiro I"],"additional_accession":[]},"is_claimable":false,"name":"Pneumococci remain the main cause of complicated pediatric pneumonia in the post-pandemic era despite extensive pneumococcal vaccine use.","description":"Nucleic acid amplification tests (NAATs) greatly enhance the capacity to identify the etiology of pediatric complicated pneumonia. However, the use of pneumococcal conjugate vaccines could reduce the importance of Streptococcus pneumoniae in pediatric complicated pneumonia with the potential emergence of other bacterial agents. Using an expanded NAAT in culture negative pleural fluid or empyema samples collected in 2010-2024 (n = 554) in Portugal, we show that S. pneumoniae remains the most frequent agent despite decades of pneumococcal conjugate vaccine use and the COVID-19 pandemic. A rebound in pediatric complicated pneumonia occurred post-pandemic, including a rise in cases by Streptococcus pyogenes and Haemophilus influenzae. Empiric therapy of pediatric complicated pneumonia should s","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-03T10:09:35.817Z","creation":"2026-04-26T03:11:38.357Z"},"accession":"S-EPMC11587768","cross_references":{"pubmed":["39582053"],"doi":["10.1186/s41479-024-00151-x"]}}