biostudies-literatureGrgurevic LUniversity of ZagrebUniversiy of Zagreb1135https://www.ebi.ac.uk/biostudies/studies/S-EPMC11592249biostudies-literatureUnknown11(11)<h4>Introduction</h4>Non-unions are fractures that do not heal properly, resulting in a false joint formation at the fracture site. This condition leads to major health issues and imposes a burden on national healthcare systems. The etiology of non-unions is still not fully understood; therefore, we aimed to identify potential systemic factors that may contribute to their formation.<h4>Materials and methods</h4>We conducted a cross-sectional concomitant proteomic and metabolomic pilot study of blood plasma in patients with non-unions (N = 11) and compared them with patients with bone fracture in the normal active healing phase (N = 12).<h4>Results</h4>We found five significantly upregulated proteins in the non-union group: immunoglobulin heavy variable 3-74, immunoglobulin lambda variable Bioengineering (Basel, Switzerland)Systemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?PMC1159224910106-24-1503Salai GJaganjac MHalasz MJambrosic LHrkac SMilosevic MVlahovic TNovak RRomic JMaticic DGrgurevic LVidovic DMocibob MfalseSystemic Lipid Metabolism Dysregulation as a Possible Driving Force of Fracture Non-Unions?<h4>Introduction</h4>Non-unions are fractures that do not heal properly, resulting in a false joint formation at the fracture site. This condition leads to major health issues and imposes a burden on national healthcare systems. The etiology of non-unions is still not fully understood; therefore, we aimed to identify potential systemic factors that may contribute to their formation.<h4>Materials and methods</h4>We conducted a cross-sectional concomitant proteomic and metabolomic pilot study of blood plasma in patients with non-unions (N = 11) and compared them with patients with bone fracture in the normal active healing phase (N = 12).<h4>Results</h4>We found five significantly upregulated proteins in the non-union group: immunoglobulin heavy variable 3-74, immunoglobulin lambda variable 2024-01-01T00:00:00Z2024 Nov2026-04-08T18:37:08.494Z2026-04-08T10:12:08.097ZS-EPMC115922493959379510.3390/bioengineering11111135