biostudies-literatureUnknown22(11)Atalay Ekiner SMinistry of Science and Higher Education (Poland)Lipid extracts from the microalgae <i>Nannochloropsis oceanica</i> and <i>Chlorococcum amblystomatis</i> have great potential to prevent ultraviolet A (UVA)-induced metabolic disorders. Therefore, the aim of this study has been to analyze their cytoprotective effect, focused on maintaining intracellular redox balance and inflammation in UVA-irradiated skin fibroblasts, at the proteome level. The above lipid extracts reversed the suppression of the antioxidant response caused by UVA radiation, which was more visible in the case of <i>C. amblystomatis</i>. Modulations of interactions between heme oxygenase-1 and matrix metalloproteinase 1/Parkinson's disease protein 7/transcript1-α/β, as well as thioredoxin and migration inhibitory factor/Parkinson's disease protein 7/calnexin/ATPase p97, crMarine drugs509https://www.ebi.ac.uk/biostudies/studies/S-EPMC11595653biostudies-literatureComparison of Microalgae <i>Nannochloropsis oceanica</i> and <i>Chlorococcum amblystomatis</i> Lipid Extracts Effects on UVA-Induced Changes in Human Skin Fibroblasts Proteome.PMC11595653Domingues PSkrzydlewska EAtalay Ekiner SGegotek ADomingues MRfalseComparison of Microalgae <i>Nannochloropsis oceanica</i> and <i>Chlorococcum amblystomatis</i> Lipid Extracts Effects on UVA-Induced Changes in Human Skin Fibroblasts Proteome.Lipid extracts from the microalgae <i>Nannochloropsis oceanica</i> and <i>Chlorococcum amblystomatis</i> have great potential to prevent ultraviolet A (UVA)-induced metabolic disorders. Therefore, the aim of this study has been to analyze their cytoprotective effect, focused on maintaining intracellular redox balance and inflammation in UVA-irradiated skin fibroblasts, at the proteome level. The above lipid extracts reversed the suppression of the antioxidant response caused by UVA radiation, which was more visible in the case of <i>C. amblystomatis</i>. Modulations of interactions between heme oxygenase-1 and matrix metalloproteinase 1/Parkinson's disease protein 7/transcript1-α/β, as well as thioredoxin and migration inhibitory factor/Parkinson's disease protein 7/calnexin/ATPase p97, cr2024-01-01T00:00:00Z2024 Nov2026-05-27T03:17:22.414Z2025-04-04T00:46:41.949ZS-EPMC115956533959078910.3390/md22110509