{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gebremedhin MB"],"funding":["Agricultural Science and Technology Innovation Program (ASTIP) of China","National Key Research and Development Program of China"],"pagination":["2269"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11596346"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(11)"],"pubmed_abstract":["The study of tick olfaction is relatively new compared to that of insects, and the molecular mechanisms involved remain poorly understood. Despite several potential chemosensory genes identified in multiple tick species, these are yet to be validated through independent functional experiments. In this research, we cloned and analyzed a microplusin-like gene, HlonML-1, and investigated its role in the chemosensory activities of <i>H. longicornis</i>. The results showed that this gene's amino acid sequences lack histidine residues essential for antimicrobial activity, and it is evolutionarily linked to putative chemosensory microplusins in ticks. Gene expression analyses indicated that HlonML-1 was significantly more abundant in ticks exposed to potential attractants and in the forelegs of <"],"journal":["Microorganisms"],"pubmed_title":["Involvement of a Microplusin-like Gene (HlonML-1) in the Olfactory Chemosensation of <i>Haemophysalis longicornis:</i> Expression, RNA Silencing, and Behavioral Implications."],"pmcid":["PMC11596346"],"funding_grant_id":["CAAS-ZDRW202203","2022YFE0120100"],"pubmed_authors":["Wei N","Cao J","Kuang C","Zhang H","Nawaz M","Zhou Y","Xu Z","Gebremedhin MB","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Involvement of a Microplusin-like Gene (HlonML-1) in the Olfactory Chemosensation of <i>Haemophysalis longicornis:</i> Expression, RNA Silencing, and Behavioral Implications.","description":"The study of tick olfaction is relatively new compared to that of insects, and the molecular mechanisms involved remain poorly understood. Despite several potential chemosensory genes identified in multiple tick species, these are yet to be validated through independent functional experiments. In this research, we cloned and analyzed a microplusin-like gene, HlonML-1, and investigated its role in the chemosensory activities of <i>H. longicornis</i>. The results showed that this gene's amino acid sequences lack histidine residues essential for antimicrobial activity, and it is evolutionarily linked to putative chemosensory microplusins in ticks. Gene expression analyses indicated that HlonML-1 was significantly more abundant in ticks exposed to potential attractants and in the forelegs of <","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-05-22T03:19:22.09Z","creation":"2025-04-04T00:43:30.393Z"},"accession":"S-EPMC11596346","cross_references":{"pubmed":["39597658"],"doi":["10.3390/microorganisms12112269"]}}