{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(11)"],"submitter":["Xie T"],"pubmed_abstract":["The FADD-like interleukin-1β converting enzyme (FLICE)-inhibitory protein (c-FLIP) plays a crucial role in various biological processes, including apoptosis and inflammation. However, the complete transcriptional profile altered by the c-FLIP is not fully understood. Furthermore, the impact of the c-FLIP deficiency on the transcriptome during a Zika virus (ZIKV) infection, which induces apoptosis and inflammation in the central nervous system (CNS), has not yet been elucidated. In this study, we compared transcriptome profiles between wild-type (WT) and the <i>c-Flip</i> heterozygous knockout mice (<i>c-Flip</i><sup>+/-</sup>) fetal heads at embryonic day 13.5 from control and PBS-infected WT dams mated with <i>c-Flip</i><sup>+/-</sup> sires. In the non-infected group, we observed differen"],"journal":["Viruses"],"pagination":["1712"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11599063"],"repository":["biostudies-literature"],"pubmed_title":["RNA-Seq Reveals Transcriptome Changes Following Zika Virus Infection in Fetal Brains in &lt;i&gt;c-Flip&lt;/i&gt; Knockdown Mice."],"pmcid":["PMC11599063"],"pubmed_authors":["Xie T","Chen Q","Wu N","Luo H","Zhang S","Luo C","Yuan J","Li N","Zou X","Jiang Y","Bai S","Tian W","Zhu L","Fang S","Shu Y","Zha H"],"additional_accession":[]},"is_claimable":false,"name":"RNA-Seq Reveals Transcriptome Changes Following Zika Virus Infection in Fetal Brains in &lt;i&gt;c-Flip&lt;/i&gt; Knockdown Mice.","description":"The FADD-like interleukin-1β converting enzyme (FLICE)-inhibitory protein (c-FLIP) plays a crucial role in various biological processes, including apoptosis and inflammation. However, the complete transcriptional profile altered by the c-FLIP is not fully understood. Furthermore, the impact of the c-FLIP deficiency on the transcriptome during a Zika virus (ZIKV) infection, which induces apoptosis and inflammation in the central nervous system (CNS), has not yet been elucidated. In this study, we compared transcriptome profiles between wild-type (WT) and the <i>c-Flip</i> heterozygous knockout mice (<i>c-Flip</i><sup>+/-</sup>) fetal heads at embryonic day 13.5 from control and PBS-infected WT dams mated with <i>c-Flip</i><sup>+/-</sup> sires. In the non-infected group, we observed differen","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-04-21T03:31:19.726Z","creation":"2025-04-04T00:46:25.097Z"},"accession":"S-EPMC11599063","cross_references":{"pubmed":["39599827"],"doi":["10.3390/v16111712"]}}