biostudies-literatureUnknown16(11)Xie TThe FADD-like interleukin-1β converting enzyme (FLICE)-inhibitory protein (c-FLIP) plays a crucial role in various biological processes, including apoptosis and inflammation. However, the complete transcriptional profile altered by the c-FLIP is not fully understood. Furthermore, the impact of the c-FLIP deficiency on the transcriptome during a Zika virus (ZIKV) infection, which induces apoptosis and inflammation in the central nervous system (CNS), has not yet been elucidated. In this study, we compared transcriptome profiles between wild-type (WT) and the <i>c-Flip</i> heterozygous knockout mice (<i>c-Flip</i>^+/-) fetal heads at embryonic day 13.5 from control and PBS-infected WT dams mated with <i>c-Flip</i>^+/- sires. In the non-infected group, we observed differenViruses1712https://www.ebi.ac.uk/biostudies/studies/S-EPMC11599063biostudies-literatureRNA-Seq Reveals Transcriptome Changes Following Zika Virus Infection in Fetal Brains in &lt;i&gt;c-Flip&lt;/i&gt; Knockdown Mice.PMC11599063Xie TChen QWu NLuo HZhang SLuo CYuan JLi NZou XJiang YBai STian WZhu LFang SShu YZha HfalseRNA-Seq Reveals Transcriptome Changes Following Zika Virus Infection in Fetal Brains in &lt;i&gt;c-Flip&lt;/i&gt; Knockdown Mice.The FADD-like interleukin-1β converting enzyme (FLICE)-inhibitory protein (c-FLIP) plays a crucial role in various biological processes, including apoptosis and inflammation. However, the complete transcriptional profile altered by the c-FLIP is not fully understood. Furthermore, the impact of the c-FLIP deficiency on the transcriptome during a Zika virus (ZIKV) infection, which induces apoptosis and inflammation in the central nervous system (CNS), has not yet been elucidated. In this study, we compared transcriptome profiles between wild-type (WT) and the <i>c-Flip</i> heterozygous knockout mice (<i>c-Flip</i>^+/-) fetal heads at embryonic day 13.5 from control and PBS-infected WT dams mated with <i>c-Flip</i>^+/- sires. In the non-infected group, we observed differen2024-01-01T00:00:00Z2024 Oct2026-04-21T03:31:19.726Z2025-04-04T00:46:25.097ZS-EPMC115990633959982710.3390/v16111712