{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hodgens C"],"funding":["NIGMS NIH HHS"],"pagination":["diae015"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11599693"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(2)"],"pubmed_abstract":["Guard cell movements depend, in part, on the remodelling of vacuoles from a highly fragmented state to a fused morphology during stomata opening. Indeed, full opening of plant stomata requires vacuole fusion to occur. Fusion of vacuole membranes is a highly conserved process in eukaryotes, with key roles played by two multi-subunit complexes: HOPS (homotypic fusion and vacuolar protein sorting) and SNARE (soluble NSF attachment protein receptor). HOPS is a vacuole tethering factor that is thought to chaperone SNAREs from apposing vacuole membranes into a fusion-competent complex capable of rearranging membranes. In plants, recruitment of HOPS subunits to the tonoplast has been shown to require the presence of the phosphoinositide phosphatidylinositol 3-phosphate. However, chemically deplet"],"journal":["In silico plants"],"pubmed_title":["Model-based inference of a dual role for HOPS in regulating guard cell vacuole fusion."],"pmcid":["PMC11599693"],"funding_grant_id":["T32 GM133366"],"pubmed_authors":["Khan I","English NJ","Rojas-Pierce M","Pullen AM","Akpa BS","Hodgens C","Flaherty DT","Gillan L"],"additional_accession":[]},"is_claimable":false,"name":"Model-based inference of a dual role for HOPS in regulating guard cell vacuole fusion.","description":"Guard cell movements depend, in part, on the remodelling of vacuoles from a highly fragmented state to a fused morphology during stomata opening. Indeed, full opening of plant stomata requires vacuole fusion to occur. Fusion of vacuole membranes is a highly conserved process in eukaryotes, with key roles played by two multi-subunit complexes: HOPS (homotypic fusion and vacuolar protein sorting) and SNARE (soluble NSF attachment protein receptor). HOPS is a vacuole tethering factor that is thought to chaperone SNAREs from apposing vacuole membranes into a fusion-competent complex capable of rearranging membranes. In plants, recruitment of HOPS subunits to the tonoplast has been shown to require the presence of the phosphoinositide phosphatidylinositol 3-phosphate. However, chemically deplet","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-05-29T09:51:47.764Z","creation":"2025-04-21T21:43:10.058Z"},"accession":"S-EPMC11599693","cross_references":{"pubmed":["39611053"],"doi":["10.1093/insilicoplants/diae015"]}}