{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marild K"],"funding":["Vetenskapsrådet","NIDDK NIH HHS","Svenska Sällskapet för Medicinsk Forskning"],"pagination":["1549-1560"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11599792"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["60(11-12)"],"pubmed_abstract":["<h4>Background</h4>Individuals with inflammatory bowel disease (IBD) are at increased risk of fracture. It is unclear if this risk varies by recent histological activity.<h4>Aims</h4>To determine the fracture risk in IBD during periods with and without histological inflammation.<h4>Methods</h4>We studied a nationwide cohort of 54,591 individuals diagnosed with IBD in 1990-2016 with longitudinal data on ileo-colorectal biopsies. Fractures were identified by inpatient and hospital-based outpatient diagnoses. We derived Cox regression estimated hazard ratios (HRs) for fracture during 12 months following a histological inflammation (vs. histological remission) record after adjusting for socio-demographics, comorbidities, IBD duration, IBD-related surgery and hospitalization. We adjusted sensit"],"journal":["Alimentary pharmacology & therapeutics"],"pubmed_title":["A nationwide cohort study of inflammatory bowel disease, histological activity and fracture risk."],"pmcid":["PMC11599792"],"funding_grant_id":["2020‐01980","2020-01980","2020-02002","K23 DK124570","2020‐02002"],"pubmed_authors":["Axelrad J","Bjork J","Olen O","Hjortswang H","Soderling J","Bengtsson J","Michaelsson K","Nordenvall C","Karling P","Olsson M","Ludvigsson JF","Andersson M","Jaghult S","Forss A","SWIBREG Study Group","Marild K","Rejler M","Eberhardson M","Fagerberg UL","Strid H","Halfvarson J","Myrelid P","Grip O"],"additional_accession":[]},"is_claimable":false,"name":"A nationwide cohort study of inflammatory bowel disease, histological activity and fracture risk.","description":"<h4>Background</h4>Individuals with inflammatory bowel disease (IBD) are at increased risk of fracture. It is unclear if this risk varies by recent histological activity.<h4>Aims</h4>To determine the fracture risk in IBD during periods with and without histological inflammation.<h4>Methods</h4>We studied a nationwide cohort of 54,591 individuals diagnosed with IBD in 1990-2016 with longitudinal data on ileo-colorectal biopsies. Fractures were identified by inpatient and hospital-based outpatient diagnoses. We derived Cox regression estimated hazard ratios (HRs) for fracture during 12 months following a histological inflammation (vs. histological remission) record after adjusting for socio-demographics, comorbidities, IBD duration, IBD-related surgery and hospitalization. We adjusted sensit","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2026-06-11T05:18:49.508Z","creation":"2025-04-04T02:45:31.58Z"},"accession":"S-EPMC11599792","cross_references":{"pubmed":["39308339"],"doi":["10.1111/apt.18275"]}}