biostudies-literatureMarild KVetenskapsrådetNIDDK NIH HHSSvenska Sällskapet för Medicinsk Forskning1549-1560https://www.ebi.ac.uk/biostudies/studies/S-EPMC11599792biostudies-literatureUnknown60(11-12)<h4>Background</h4>Individuals with inflammatory bowel disease (IBD) are at increased risk of fracture. It is unclear if this risk varies by recent histological activity.<h4>Aims</h4>To determine the fracture risk in IBD during periods with and without histological inflammation.<h4>Methods</h4>We studied a nationwide cohort of 54,591 individuals diagnosed with IBD in 1990-2016 with longitudinal data on ileo-colorectal biopsies. Fractures were identified by inpatient and hospital-based outpatient diagnoses. We derived Cox regression estimated hazard ratios (HRs) for fracture during 12 months following a histological inflammation (vs. histological remission) record after adjusting for socio-demographics, comorbidities, IBD duration, IBD-related surgery and hospitalization. We adjusted sensitAlimentary pharmacology & therapeuticsA nationwide cohort study of inflammatory bowel disease, histological activity and fracture risk.PMC115997922020‐019802020-019802020-02002K23 DK1245702020‐02002Axelrad JBjork JOlen OHjortswang HSoderling JBengtsson JMichaelsson KNordenvall CKarling POlsson MLudvigsson JFAndersson MJaghult SForss ASWIBREG Study GroupMarild KRejler MEberhardson MFagerberg ULStrid HHalfvarson JMyrelid PGrip OfalseA nationwide cohort study of inflammatory bowel disease, histological activity and fracture risk.<h4>Background</h4>Individuals with inflammatory bowel disease (IBD) are at increased risk of fracture. It is unclear if this risk varies by recent histological activity.<h4>Aims</h4>To determine the fracture risk in IBD during periods with and without histological inflammation.<h4>Methods</h4>We studied a nationwide cohort of 54,591 individuals diagnosed with IBD in 1990-2016 with longitudinal data on ileo-colorectal biopsies. Fractures were identified by inpatient and hospital-based outpatient diagnoses. We derived Cox regression estimated hazard ratios (HRs) for fracture during 12 months following a histological inflammation (vs. histological remission) record after adjusting for socio-demographics, comorbidities, IBD duration, IBD-related surgery and hospitalization. We adjusted sensit2024-01-01T00:00:00Z2024 Dec2026-06-11T05:18:49.508Z2025-04-04T02:45:31.58ZS-EPMC115997923930833910.1111/apt.18275