biostudies-literatureHuffman JEBLRD VANHLBI NIH HHSNIMHD NIH HHSNNF Center for Basic Metabolic Research2248-2265https://www.ebi.ac.uk/biostudies/studies/S-EPMC11600029biostudies-literatureUnknown144(21)<h4>Abstract</h4>Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared with array-based genotyping, whole-genome sequencing (WGS) data provide better coverage of the genome and better representation of non-European variants. To better understand the genetic landscape regulating plasma fibrinogen levels, we meta-analyzed WGS data from the National Heart, Lung, and Blood Institute's Trans-Omics for Precision Medicine (TOPMed) program (n = 32 572), with array-based genotype data from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (n = 131 340) imputed to the TOPMed or Haplotype BloodWhole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.PMC11600029Hansen GroupR01 HL134894R01 HL120393R01 HL113323R01 HL141291R01 HL117626R01 HL153805Kilpeläinen GroupU01 HL120393HHSN268201800001CI01 BX004821R01 HL139553R01 HL126974P01 HL045522R01 HL105756R01 MD012564Ekunwe LPankratz NPsaty BMFaraday NKardia SLRLewis JPGuo XJukema JWRosendaal FRBielak LFMorrison ACLuan JMenni CChasman DIKleber MEHarris SECarrasquilla GDIkram MAMook-Kanamori DOO'Connell JRHayward CDehghan ANicholas JFloyd JSBoomsma DBeswick AReiner AGreinacher AHahn JBartz TMWatkins HSuchon PRedline SSouto JCCox SRWolberg ASMarioni RENoordam RDavies GTregouet DAYanek LRBecker LCMalmberg AHuffman JEZare MLee JZhao WBlangero JSilverman EKSabater-Lleal MLi-Gao RHoward TBrown MRWareham NJSmith JARidker PMvan Rooij FJAAlmasy LRaikkonen KWilson PWFVolker URichmond AMathias RAChen MHOrru VKooperberg CNaitza SGrarup NAuer PMitchell BDde Vries PSGogele MRotter JIKolcic IJohnson ADde Geus ERich SSElliott PGao HWang HStott DJWilson JFHaessler JEmmert DBBowler RPCurran JESpector TDPauls-Verges FRodriguez BATJoshi PKLahti JYao JRaffield LMWillemsen GMorange PEEriksson JGCho MHFiorillo EKilpelainen TODeleuze JFBrody JAHeath ASLange LAFornage MMarz WLinneberg Avan Hylckama Vlieg APolasek OSoria JMChristofidou PCrapo JDFuchsberger CThibord FSmith NLCho KPramstaller PPMangino MWeiss Sde Maat MPMNauck MRyan KAHottenga JJMartinez-Perez AGhanbari MRudan IPedersen OHou LCampbell HHansen TDelgado GECade BESteri MBen-Shlomo YLe NQDoyle MTrompet SfalseWhole-genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.<h4>Abstract</h4>Genetic studies have identified numerous regions associated with plasma fibrinogen levels in Europeans, yet missing heritability and limited inclusion of non-Europeans necessitates further studies with improved power and sensitivity. Compared with array-based genotyping, whole-genome sequencing (WGS) data provide better coverage of the genome and better representation of non-European variants. To better understand the genetic landscape regulating plasma fibrinogen levels, we meta-analyzed WGS data from the National Heart, Lung, and Blood Institute's Trans-Omics for Precision Medicine (TOPMed) program (n = 32 572), with array-based genotype data from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (n = 131 340) imputed to the TOPMed or Haplotype 2024-01-01T00:00:00Z2024 Nov2026-06-05T17:47:22.171Z2026-05-19T03:11:55.804ZS-EPMC116000293922646210.1182/blood.2023022596