{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nie J"],"funding":["Natural Science Basic Research Program of Shaanxi Province","National Natural Science Foundation of China","Outstanding Youth Science Foundation Project of Shaanxi Provincial Department of Science and Technology"],"pagination":["e2405127"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11600210"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(44)"],"pubmed_abstract":["Autophagy plays an important role in determining stem-cell differentiation. During the osteogenic differentiation of mesenchymal stem cells (MSCs), autophagosome formation is upregulated but the reason is unknown. A long-standing quest in the autophagy field is to find the membrane origin of autophagosomes. In this study, cytoplasmic coat protein complex II (COPII) vesicles, endoplasmic reticulum-derived vesicles responsible for the transport of storage proteins to the Golgi, are demonstrated to be a critical source of osteoblastic autophagosomal membrane. A significant correlation between the number of COPII vesicle and the autophagy level is identified in the rat bone tissues. Disruption of COPII vesicles restrained osteogenesis and decreased the number and size of autophagosomes. SEC31a"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["SEC31a-ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation."],"pmcid":["PMC11600210"],"funding_grant_id":["2022JC-57","82170927","2023-JC-QN-0842","2023‐JC‐QN‐0842"],"pubmed_authors":["Li Y","Ma S","Wu L","Cao J","Nie J","Cooper PR","Li A","Mei P","Li M","Pei D"],"additional_accession":[]},"is_claimable":false,"name":"SEC31a-ATG9a Interaction Mediates the Recruitment of COPII Vesicles for Autophagosome Formation.","description":"Autophagy plays an important role in determining stem-cell differentiation. During the osteogenic differentiation of mesenchymal stem cells (MSCs), autophagosome formation is upregulated but the reason is unknown. A long-standing quest in the autophagy field is to find the membrane origin of autophagosomes. In this study, cytoplasmic coat protein complex II (COPII) vesicles, endoplasmic reticulum-derived vesicles responsible for the transport of storage proteins to the Golgi, are demonstrated to be a critical source of osteoblastic autophagosomal membrane. A significant correlation between the number of COPII vesicle and the autophagy level is identified in the rat bone tissues. Disruption of COPII vesicles restrained osteogenesis and decreased the number and size of autophagosomes. SEC31a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-05T09:30:48.419Z","creation":"2025-04-05T09:30:48.419Z"},"accession":"S-EPMC11600210","cross_references":{"pubmed":["39361436"],"doi":["10.1002/advs.202405127"]}}