biostudies-literatureUnknown22(1)Wang B<h4>Background</h4>Effective screening for colorectal cancer (CRC) enables earlier diagnosis and intervention to improve patient survival.<h4>Methods</h4>In this study, we prospectively conducted a blood-based CRC screening program for community residents in Hanjiang District, Yangzhou City, and evaluated the screening efficacy of a blood-based multi-locus DNA methylation assay (ColonAiQ). The ColonAiQ-positive rate and colonoscopy participation rate of the population, detection rate of intestinal lesions, and positive predictive value (PPV) of CRC and advanced adenoma (AA) were calculated, and the associated factors were explored.<h4>Results</h4>A total of 105,285 participants were enrolled from January 2021 to December 2022, all of whom completed the ColonAiQ assay, yielding a positive rBMC medicine560https://www.ebi.ac.uk/biostudies/studies/S-EPMC11600563biostudies-literatureColorectal cancer screening using a multi-locus blood-based assay targeting circulating tumor DNA methylation: a cross-sectional study in an average-risk population.PMC11600563Liu HYang HPan WWu JLiu JWang BWang CYuan QLi FSui YXu DJia HLi QLiu RFang JYXiao QLiu WDeng BWang NLi YDing YZhang YChen YWang YfalseColorectal cancer screening using a multi-locus blood-based assay targeting circulating tumor DNA methylation: a cross-sectional study in an average-risk population.<h4>Background</h4>Effective screening for colorectal cancer (CRC) enables earlier diagnosis and intervention to improve patient survival.<h4>Methods</h4>In this study, we prospectively conducted a blood-based CRC screening program for community residents in Hanjiang District, Yangzhou City, and evaluated the screening efficacy of a blood-based multi-locus DNA methylation assay (ColonAiQ). The ColonAiQ-positive rate and colonoscopy participation rate of the population, detection rate of intestinal lesions, and positive predictive value (PPV) of CRC and advanced adenoma (AA) were calculated, and the associated factors were explored.<h4>Results</h4>A total of 105,285 participants were enrolled from January 2021 to December 2022, all of whom completed the ColonAiQ assay, yielding a positive r2024-01-01T00:00:00Z2024 Nov2026-06-01T10:00:22.159Z2025-04-04T00:46:05.967ZS-EPMC116005633960491310.1186/s12916-024-03777-2