biostudies-literatureRaez-Bravo AMinisterio de Economía y CompetitividadJunta de Andalucía1144https://www.ebi.ac.uk/biostudies/studies/S-EPMC11600671biostudies-literatureUnknown25(1)<h4>Background</h4>Sarcoptic mange is an emerging and neglected contagious skin disease caused by the mite Sarcoptes scabiei, affecting humans, domestic animals, and wildlife. Mange is the main disease and a major concern for the management and conservation of populations of Iberian ibex (Capra pyrenaica), a medium-sized mountain ungulate endemic to the Iberian Peninsula and Northern Pyrenees. Differences in host-parasite interaction and host immune response determine mange clinical outcome, but little is known about the related differences in gene expression. This study determined blood and skin gene expressions in S. scabiei-experimentally infested Iberian ibexes.<h4>Results</h4>Infestation with S. scabiei promoted immune and inflammatory genomic responses both in skin and blood, with twBMC genomicsGenomics reveal local skin immune response key to control sarcoptic mange in Iberian ibex (Capra pyrenaica).PMC11600671PAIDI RNM-118CGL2012-40043-C02-01, CGL2012-40043-CO2-02, CGL2016-80543-PCano-Manuel FJEspinosa JNonell LPerez JMLopez-Olvera JRSerrano EBodalo MPuigdecanet ESoriguer RCFandos PRaez-Bravo AGranados JEfalseGenomics reveal local skin immune response key to control sarcoptic mange in Iberian ibex (Capra pyrenaica).<h4>Background</h4>Sarcoptic mange is an emerging and neglected contagious skin disease caused by the mite Sarcoptes scabiei, affecting humans, domestic animals, and wildlife. Mange is the main disease and a major concern for the management and conservation of populations of Iberian ibex (Capra pyrenaica), a medium-sized mountain ungulate endemic to the Iberian Peninsula and Northern Pyrenees. Differences in host-parasite interaction and host immune response determine mange clinical outcome, but little is known about the related differences in gene expression. This study determined blood and skin gene expressions in S. scabiei-experimentally infested Iberian ibexes.<h4>Results</h4>Infestation with S. scabiei promoted immune and inflammatory genomic responses both in skin and blood, with tw2024-01-01T00:00:00Z2024 Nov2025-04-04T02:54:20.959Z2025-04-04T02:54:20.959ZS-EPMC116006713960487710.1186/s12864-024-10999-4