{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Teskey G"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pubmed_abstract":["The storage and release of triacylglycerol (TAG) in lipid droplets (LDs) is regulated by dynamic protein interactions. α/β hydrolase domain-containing protein 5 (ABHD5; also known as CGI-58) is a membrane/LD bound protein that functions as a co-activator of Patatin Like Phospholipase Domain Containing 2 (PNPLA2; also known as Adipose triglyceride lipase, ATGL) the rate-limiting enzyme for TAG hydrolysis. The dysregulation of TAG hydrolysis is involved in various metabolic diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD). We previously demonstrated that ABHD5 interacted with PNPLA3, a closely related family member to PNPLA2. Importantly, a common missense variant in PNPLA3 (I148M) is the greatest genetic risk factor for MASLD. PNPLA3 148M functions to seques"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.10.03.616525"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11601262"],"repository":["biostudies-literature"],"pubmed_title":["Lipid droplet targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosis."],"pmcid":["PMC11601262"],"funding_grant_id":["P30 DK092926","T32 HL120822","R01 DK126743"],"pubmed_authors":["Butcko AJ","Huang YM","Kelly CV","Mottillo EP","Tiwari N","Granneman JG","Perfield JW","Teskey G","Kumar A","Yadav A"],"additional_accession":[]},"is_claimable":false,"name":"Lipid droplet targeting of ABHD5 and PNPLA3 I148M is required to promote liver steatosis.","description":"The storage and release of triacylglycerol (TAG) in lipid droplets (LDs) is regulated by dynamic protein interactions. α/β hydrolase domain-containing protein 5 (ABHD5; also known as CGI-58) is a membrane/LD bound protein that functions as a co-activator of Patatin Like Phospholipase Domain Containing 2 (PNPLA2; also known as Adipose triglyceride lipase, ATGL) the rate-limiting enzyme for TAG hydrolysis. The dysregulation of TAG hydrolysis is involved in various metabolic diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD). We previously demonstrated that ABHD5 interacted with PNPLA3, a closely related family member to PNPLA2. Importantly, a common missense variant in PNPLA3 (I148M) is the greatest genetic risk factor for MASLD. PNPLA3 148M functions to seques","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-04-16T03:28:15.052Z","creation":"2025-04-06T01:56:07.792Z"},"accession":"S-EPMC11601262","cross_references":{"pubmed":["39605541"],"doi":["10.1101/2024.10.03.616525"]}}