{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Brusman LE"],"funding":["NIMH NIH HHS","NHLBI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["As relationships mature, partners share common goals, improve their ability to work together, and experience coordinated emotions. However, the neural underpinnings responsible for this unique, pair-specific experience remain largely unexplored. Here, we used single nucleus RNA-sequencing to examine the transcriptional landscape of the nucleus accumbens (NAc) in socially monogamous prairie voles in peer or mating-based relationships. We show that, regardless of pairing type, prairie voles exhibit transcriptional synchrony with a partner. Further, we identify genes expressed in oligodendrocyte progenitor cells that are synchronized between partners, correlated with dyadic behavior, and sensitive to partner separation. Together, our data indicate that the pair-specific social environment pro"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.03.27.587112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11601461"],"repository":["biostudies-literature"],"pubmed_title":["Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships."],"pmcid":["PMC11601461"],"funding_grant_id":["UF1 NS122124","F31 MH132278","U01 NS131406","R01 HL156475","T32 GM142607","R01 MH119421","T32 GM008759","R01 MH125423"],"pubmed_authors":["Sadino JM","Allen MA","Brusman LE","Dowell RD","Donaldson ZR","Kelberman MA","Fultz AC"],"additional_accession":[]},"is_claimable":false,"name":"Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships.","description":"As relationships mature, partners share common goals, improve their ability to work together, and experience coordinated emotions. However, the neural underpinnings responsible for this unique, pair-specific experience remain largely unexplored. Here, we used single nucleus RNA-sequencing to examine the transcriptional landscape of the nucleus accumbens (NAc) in socially monogamous prairie voles in peer or mating-based relationships. We show that, regardless of pairing type, prairie voles exhibit transcriptional synchrony with a partner. Further, we identify genes expressed in oligodendrocyte progenitor cells that are synchronized between partners, correlated with dyadic behavior, and sensitive to partner separation. Together, our data indicate that the pair-specific social environment pro","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-04T02:32:50.081Z","creation":"2025-04-04T02:32:50.081Z"},"accession":"S-EPMC11601461","cross_references":{"pubmed":["39605537"],"doi":["10.1101/2024.03.27.587112"]}}