biostudies-literatureUnknownBrusman LENIMH NIH HHSNHLBI NIH HHSNINDS NIH HHSNIGMS NIH HHSAs relationships mature, partners share common goals, improve their ability to work together, and experience coordinated emotions. However, the neural underpinnings responsible for this unique, pair-specific experience remain largely unexplored. Here, we used single nucleus RNA-sequencing to examine the transcriptional landscape of the nucleus accumbens (NAc) in socially monogamous prairie voles in peer or mating-based relationships. We show that, regardless of pairing type, prairie voles exhibit transcriptional synchrony with a partner. Further, we identify genes expressed in oligodendrocyte progenitor cells that are synchronized between partners, correlated with dyadic behavior, and sensitive to partner separation. Together, our data indicate that the pair-specific social environment probioRxiv : the preprint server for biology2024.03.27.587112https://www.ebi.ac.uk/biostudies/studies/S-EPMC11601461biostudies-literatureSingle nucleus RNA-sequencing reveals transcriptional synchrony across different relationships.PMC11601461UF1 NS122124F31 MH132278U01 NS131406R01 HL156475T32 GM142607R01 MH119421T32 GM008759R01 MH125423Sadino JMAllen MABrusman LEDowell RDDonaldson ZRKelberman MAFultz ACfalseSingle nucleus RNA-sequencing reveals transcriptional synchrony across different relationships.As relationships mature, partners share common goals, improve their ability to work together, and experience coordinated emotions. However, the neural underpinnings responsible for this unique, pair-specific experience remain largely unexplored. Here, we used single nucleus RNA-sequencing to examine the transcriptional landscape of the nucleus accumbens (NAc) in socially monogamous prairie voles in peer or mating-based relationships. We show that, regardless of pairing type, prairie voles exhibit transcriptional synchrony with a partner. Further, we identify genes expressed in oligodendrocyte progenitor cells that are synchronized between partners, correlated with dyadic behavior, and sensitive to partner separation. Together, our data indicate that the pair-specific social environment pro2024-01-01T00:00:00Z2024 Nov2025-04-04T02:32:50.081Z2025-04-04T02:32:50.081ZS-EPMC116014613960553710.1101/2024.03.27.587112