biostudies-literatureUnknownMichel JCNICHD NIH HHSNEI NIH HHSNINDS NIH HHSNCI NIH HHSNIGMS NIH HHSNeuronal circuits are composed of synapses that are either chemical, where signals are transmitted via neurotransmitter release and reception, or electrical, where signals pass directly through interneuronal gap junction channels. While the molecular complexity that controls chemical synapse structure and function is well appreciated, the proteins of electrical synapses beyond the gap-junction-forming Connexins are not well defined. Yet, electrical synapses are expected to be molecularly complex beyond the gap junctions. Connexins are integral membrane proteins requiring vesicular transport and membrane insertion/retrieval to achieve function, homeostasis, and plasticity. Additionally, electron microscopy of neuronal gap junctions reveals neighboring electron dense regions termed the electbioRxiv : the preprint server for biology2024.11.22.624763https://www.ebi.ac.uk/biostudies/studies/S-EPMC11601576biostudies-literatureElectrical synapse molecular diversity revealed by proximity-based proteomic discovery.PMC11601576F32 HD102182P30 CA069533R01 NS105758P30 EY010572T32 GM007413R21 NS117967Michel JCBranon TCMiller ACLukowicz-Bedford RMMartin EACrow WEKissinger JSHorrocks MTing AYfalseElectrical synapse molecular diversity revealed by proximity-based proteomic discovery.Neuronal circuits are composed of synapses that are either chemical, where signals are transmitted via neurotransmitter release and reception, or electrical, where signals pass directly through interneuronal gap junction channels. While the molecular complexity that controls chemical synapse structure and function is well appreciated, the proteins of electrical synapses beyond the gap-junction-forming Connexins are not well defined. Yet, electrical synapses are expected to be molecularly complex beyond the gap junctions. Connexins are integral membrane proteins requiring vesicular transport and membrane insertion/retrieval to achieve function, homeostasis, and plasticity. Additionally, electron microscopy of neuronal gap junctions reveals neighboring electron dense regions termed the elect2024-01-01T00:00:00Z2024 Nov2025-04-04T02:17:13.078Z2025-04-04T02:17:13.078ZS-EPMC116015763960553510.1101/2024.11.22.624763