{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Moreau CA"],"funding":["NIMH NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Early-onset restrictive eating disorders (rEO-ED) encompass a heterogeneous group of conditions, including early-onset anorexia nervosa (EO-AN) and avoidant restrictive food intake disorders (ARFID). Almost nothing is known about the consequences of rEO-ED on brain development.<h4>Methods</h4>We performed the largest comparison of MRI-derived brain features in children and early adolescents (<13 years) with EO-AN (n=124), ARFID (n=50), and typically developing individuals (TD, n=112).<h4>Results</h4>Despite similar body mass index (BMI) distributions, EO-AN and ARFID showed divergent structural patterns, suggesting independent brain mechanisms. Half the regional brain measures were correlated with BMI in EO-AN and none in ARFID, indicating a partial mediation of EO-AN si"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2024.11.12.24317128"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11601758"],"repository":["biostudies-literature"],"pubmed_title":["Neuroimaging Insights into Brain Mechanisms of Early-onset Restrictive Eating Disorders."],"pmcid":["PMC11601758"],"funding_grant_id":["U01 MH136221"],"pubmed_authors":["Ayrolles A","Stordeur C","Bergeret P","Alison M","Elmaleh-Berges M","Bourgeron T","Ehrlich S","Delorme R","Moreau CA","Traut N","Germanaud D","Bonicel R","Ching CRK","Mathieu A","Thompson PM","Tran L"],"additional_accession":[]},"is_claimable":false,"name":"Neuroimaging Insights into Brain Mechanisms of Early-onset Restrictive Eating Disorders.","description":"<h4>Background</h4>Early-onset restrictive eating disorders (rEO-ED) encompass a heterogeneous group of conditions, including early-onset anorexia nervosa (EO-AN) and avoidant restrictive food intake disorders (ARFID). Almost nothing is known about the consequences of rEO-ED on brain development.<h4>Methods</h4>We performed the largest comparison of MRI-derived brain features in children and early adolescents (<13 years) with EO-AN (n=124), ARFID (n=50), and typically developing individuals (TD, n=112).<h4>Results</h4>Despite similar body mass index (BMI) distributions, EO-AN and ARFID showed divergent structural patterns, suggesting independent brain mechanisms. Half the regional brain measures were correlated with BMI in EO-AN and none in ARFID, indicating a partial mediation of EO-AN si","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-08-14T03:04:57.827Z","creation":"2025-04-06T22:42:51.363Z"},"accession":"S-EPMC11601758","cross_references":{"pubmed":["39606373"],"doi":["10.1101/2024.11.12.24317128"]}}