biostudies-literatureUnknownMoreau CANIMH NIH HHS<h4>Background</h4>Early-onset restrictive eating disorders (rEO-ED) encompass a heterogeneous group of conditions, including early-onset anorexia nervosa (EO-AN) and avoidant restrictive food intake disorders (ARFID). Almost nothing is known about the consequences of rEO-ED on brain development.<h4>Methods</h4>We performed the largest comparison of MRI-derived brain features in children and early adolescents (<13 years) with EO-AN (n=124), ARFID (n=50), and typically developing individuals (TD, n=112).<h4>Results</h4>Despite similar body mass index (BMI) distributions, EO-AN and ARFID showed divergent structural patterns, suggesting independent brain mechanisms. Half the regional brain measures were correlated with BMI in EO-AN and none in ARFID, indicating a partial mediation of EO-AN simedRxiv : the preprint server for health sciences2024.11.12.24317128https://www.ebi.ac.uk/biostudies/studies/S-EPMC11601758biostudies-literatureNeuroimaging Insights into Brain Mechanisms of Early-onset Restrictive Eating Disorders.PMC11601758U01 MH136221Ayrolles AStordeur CBergeret PAlison MElmaleh-Berges MBourgeron TEhrlich SDelorme RMoreau CATraut NGermanaud DBonicel RChing CRKMathieu AThompson PMTran LfalseNeuroimaging Insights into Brain Mechanisms of Early-onset Restrictive Eating Disorders.<h4>Background</h4>Early-onset restrictive eating disorders (rEO-ED) encompass a heterogeneous group of conditions, including early-onset anorexia nervosa (EO-AN) and avoidant restrictive food intake disorders (ARFID). Almost nothing is known about the consequences of rEO-ED on brain development.<h4>Methods</h4>We performed the largest comparison of MRI-derived brain features in children and early adolescents (<13 years) with EO-AN (n=124), ARFID (n=50), and typically developing individuals (TD, n=112).<h4>Results</h4>Despite similar body mass index (BMI) distributions, EO-AN and ARFID showed divergent structural patterns, suggesting independent brain mechanisms. Half the regional brain measures were correlated with BMI in EO-AN and none in ARFID, indicating a partial mediation of EO-AN si2024-01-01T00:00:00Z2024 Nov2025-08-14T03:04:57.827Z2025-04-06T22:42:51.363ZS-EPMC116017583960637310.1101/2024.11.12.24317128