{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen M"],"funding":["the National Institute of Health","NIDDK NIH HHS","NIA NIH HHS","NHLBI NIH HHS"],"pagination":["e181172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11601894"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(22)"],"pubmed_abstract":["BACKGROUNDLeft ventricular hypertrophy (LVH) and dyslipidemia are strong, independent predictors for cardiovascular disease, but their relationship is less well studied. A longitudinal lipidomic profiling of left ventricular mass (LVM) and LVH is still lacking.METHODSUsing liquid chromatography-mass spectrometry (LC-MS), we repeatedly measured 1,542 lipids from 1,755 unique American Indians attending 2 exams (mean, 5 years apart). Cross-sectional associations of individual lipid species with LVM index (LVMI) were examined by generalized estimating equation (GEE), followed by replication in an independent biracial cohort (65% White, 35% Black). Baseline plasma lipids associated with LVH risk beyond traditional risk factors were identified by logistic GEE model in American Indians. Longitudi"],"journal":["JCI insight"],"pubmed_title":["Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians."],"pmcid":["PMC11601894"],"funding_grant_id":["75N92019D00028","R01 HL109315","75N92019D00027","K01 HL161538","75N92019D00029","R01 HL109301","R01DK107532","R01 HL109284","R01 HL109282","U01 HL041652","U01 HL065520","U01 HL065521","U01 HL041642","U01 HL041654","R01 DK107532","75N92019D00030","R21 AG051914","R01 HL109319"],"pubmed_authors":["Liu J","Cole SA","Chen M","Devereux RB","Miao G","Huang Z","Ren J","Zhang Y","Fiehn O","Fabsitz RR","Kelly TN","Umans JG","Roman MJ","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians.","description":"BACKGROUNDLeft ventricular hypertrophy (LVH) and dyslipidemia are strong, independent predictors for cardiovascular disease, but their relationship is less well studied. A longitudinal lipidomic profiling of left ventricular mass (LVM) and LVH is still lacking.METHODSUsing liquid chromatography-mass spectrometry (LC-MS), we repeatedly measured 1,542 lipids from 1,755 unique American Indians attending 2 exams (mean, 5 years apart). Cross-sectional associations of individual lipid species with LVM index (LVMI) were examined by generalized estimating equation (GEE), followed by replication in an independent biracial cohort (65% White, 35% Black). Baseline plasma lipids associated with LVH risk beyond traditional risk factors were identified by logistic GEE model in American Indians. Longitudi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2025-04-19T17:34:42.546Z","creation":"2025-04-19T17:34:42.546Z"},"accession":"S-EPMC11601894","cross_references":{"pubmed":["39405119"],"doi":["10.1172/jci.insight.181172"]}}