biostudies-literatureChen Mthe National Institute of HealthNIDDK NIH HHSNIA NIH HHSNHLBI NIH HHSe181172https://www.ebi.ac.uk/biostudies/studies/S-EPMC11601894biostudies-literatureUnknown9(22)BACKGROUNDLeft ventricular hypertrophy (LVH) and dyslipidemia are strong, independent predictors for cardiovascular disease, but their relationship is less well studied. A longitudinal lipidomic profiling of left ventricular mass (LVM) and LVH is still lacking.METHODSUsing liquid chromatography-mass spectrometry (LC-MS), we repeatedly measured 1,542 lipids from 1,755 unique American Indians attending 2 exams (mean, 5 years apart). Cross-sectional associations of individual lipid species with LVM index (LVMI) were examined by generalized estimating equation (GEE), followed by replication in an independent biracial cohort (65% White, 35% Black). Baseline plasma lipids associated with LVH risk beyond traditional risk factors were identified by logistic GEE model in American Indians. LongitudiJCI insightLongitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians.PMC1160189475N92019D00028R01 HL10931575N92019D00027K01 HL16153875N92019D00029R01 HL109301R01DK107532R01 HL109284R01 HL109282U01 HL041652U01 HL065520U01 HL065521U01 HL041642U01 HL041654R01 DK10753275N92019D00030R21 AG051914R01 HL109319Liu JCole SAChen MDevereux RBMiao GHuang ZRen JZhang YFiehn OFabsitz RRKelly TNUmans JGRoman MJZhao JfalseLongitudinal lipidomic profiles of left ventricular mass and left ventricular hypertrophy in American Indians.BACKGROUNDLeft ventricular hypertrophy (LVH) and dyslipidemia are strong, independent predictors for cardiovascular disease, but their relationship is less well studied. A longitudinal lipidomic profiling of left ventricular mass (LVM) and LVH is still lacking.METHODSUsing liquid chromatography-mass spectrometry (LC-MS), we repeatedly measured 1,542 lipids from 1,755 unique American Indians attending 2 exams (mean, 5 years apart). Cross-sectional associations of individual lipid species with LVM index (LVMI) were examined by generalized estimating equation (GEE), followed by replication in an independent biracial cohort (65% White, 35% Black). Baseline plasma lipids associated with LVH risk beyond traditional risk factors were identified by logistic GEE model in American Indians. Longitudi2024-01-01T00:00:00Z2024 Oct2025-04-19T17:34:42.546Z2025-04-19T17:34:42.546ZS-EPMC116018943940511910.1172/jci.insight.181172