{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uddin J"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NIH Office of the Director"],"pagination":["e172978"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11601949"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(22)"],"pubmed_abstract":["Susceptibility to inflammatory bowel diseases (IBDs), Crohn's disease (CD), and ulcerative colitis (UC) is linked with loss of intestinal epithelial barrier integrity and mitochondria dysfunction. Steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain-containing protein 7 (STARD7) is a phosphatidylcholine-specific (PC-specific) lipid transfer protein that transports PC from the ER to the mitochondria, facilitating mitochondria membrane stabilization and respiration function. The aim of this study was to define the contribution of STARD7 in the regulation of the intestinal epithelial mitochondrial function and susceptibility to colitis. In silico analyses identified significantly reduced expression of STARD7 in patients with UC, which was associated with downreg"],"journal":["JCI insight"],"pubmed_title":["STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis."],"pmcid":["PMC11601949"],"funding_grant_id":["R01 AI112626","P30 DK078392","R37AI112626","R01 DK099222","R21 AI138177","R01 DK090119","R37 AI112626","T32 AI007413","DK073553,DK090119,DK125007,DK099222,AI138177,AI112626,AI007413","F31 DK125007"],"pubmed_authors":["Thota LNR","Hogan SP","O'Dwyer DN","Marella S","Reynolds MB","Haberman Y","Wu D","Uddin J","Denson LA","Ganesan V","Reichel PE","Divanovic S","Sharma A","Parkos CA","Tomar S","Weaver TE","Raya-Sandino A","Idelman G","Lukacs NW","O'Riordan MX","Nusrat A","Cabrera-Silva RI","Tay HL","Elesela S"],"additional_accession":[]},"is_claimable":false,"name":"STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis.","description":"Susceptibility to inflammatory bowel diseases (IBDs), Crohn's disease (CD), and ulcerative colitis (UC) is linked with loss of intestinal epithelial barrier integrity and mitochondria dysfunction. Steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain-containing protein 7 (STARD7) is a phosphatidylcholine-specific (PC-specific) lipid transfer protein that transports PC from the ER to the mitochondria, facilitating mitochondria membrane stabilization and respiration function. The aim of this study was to define the contribution of STARD7 in the regulation of the intestinal epithelial mitochondrial function and susceptibility to colitis. In silico analyses identified significantly reduced expression of STARD7 in patients with UC, which was associated with downreg","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-03T00:52:46.36Z","creation":"2025-04-06T15:06:21.705Z"},"accession":"S-EPMC11601949","cross_references":{"pubmed":["39576011"],"doi":["10.1172/jci.insight.172978"]}}