{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zou HM"],"funding":["Natural Science Foundation of Guizhou Province","National Natural Science Foundation of China","Science and Technology Foundation of Guizhou Provincial Health Commission","National Natural Science Foundation of China’s (NSFC) Cultivation Project"],"pagination":["e001349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11603702"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(2)"],"pubmed_abstract":["Objective
The current study aims to elucidate the critical function of hepatocyte nuclear factor 1-beta (HNF1-β) in lupus nephritis (LN) by investigating its modulation of the Derlin-1/valosin-containing protein (VCP)/VCP-interacting membrane selenoprotein (VIMP) complex, endoplasmic reticulum (ER) stress and podocyte apoptosis.Methods
In vitro and in vivo models of LN were established using glomerular podocytes treated with LN serum and MRL/lpr mice, respectively. The expression levels of HNF1-β were analysed in kidney tissues from patients with LN and MRL/lpr mice. To assess the effects of HNF1-β inhibition, an adeno-associated virus vector carrying HNF1-β short hairpin was administered to MRL/lpr mice. In vitro, glomerular podocytes were transfected with HNF1-β small int"],"journal":["Lupus science & medicine"],"pubmed_title":["HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis."],"pmcid":["PMC11603702"],"funding_grant_id":["82360147","gyfynsfc[2022]-53","QianKeHeJiChu-ZK[2022] General 378","gzwkj2023-209","82460148","QianKeHeJiChu-ZK[2022] General 409"],"pubmed_authors":["Zhang F","Liu J","Zou HM","Xie Y","Shi MJ","Liu M","Luo YQ","Yu J","An XM","Xu LF","Chen PL","Guo B","Ruan YY"],"additional_accession":[]},"is_claimable":false,"name":"HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis.","description":"Objective
The current study aims to elucidate the critical function of hepatocyte nuclear factor 1-beta (HNF1-β) in lupus nephritis (LN) by investigating its modulation of the Derlin-1/valosin-containing protein (VCP)/VCP-interacting membrane selenoprotein (VIMP) complex, endoplasmic reticulum (ER) stress and podocyte apoptosis.Methods
In vitro and in vivo models of LN were established using glomerular podocytes treated with LN serum and MRL/lpr mice, respectively. The expression levels of HNF1-β were analysed in kidney tissues from patients with LN and MRL/lpr mice. To assess the effects of HNF1-β inhibition, an adeno-associated virus vector carrying HNF1-β short hairpin was administered to MRL/lpr mice. In vitro, glomerular podocytes were transfected with HNF1-β small int","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-19T04:22:25.35Z","creation":"2025-04-19T04:22:25.35Z"},"accession":"S-EPMC11603702","cross_references":{"pubmed":["39608815"],"doi":["10.1136/lupus-2024-001349"]}}